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时间:2018-05-08
《激活k阿片受体与远程预处理诱导心肌缺血耐受的作用的论文》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、激活K阿片受体与远程预处理诱导心肌缺血耐受的作用的论文【摘要】目的:比较k阿片受体激动剂u50488h预处理与远程预处理诱导心肌缺血耐受对心肌梗塞(mi)范围与心肌酶的影响。方法:32只雄性新西兰大白兔随机分成四组(各组8例):对照组、u50488h组、远程缺血预处理(rpc)组和选择性k阿片受体阻断剂(nor-bni)+u50488h组。对照组心肌缺血前1.5h静脉给予戊巴比妥钠30mg/kg;rpc组在心肌缺血前1.5h静脉给予戊巴比妥钠30mg/kg麻醉动物后,行双后肢短暂缺血预处理2次(充气式压力止血带环扎双后肢腘窝上1/3,压力26.6kpa,每次10min,间隔1
2、0min);u50488h组在心肌缺血前105min静脉注射u50488h1.5mg/kg,余同rpc组;nor-bni+u50488h组在预处理前15min给予nor-bni2mg/kg,余同u50488h组。各组最后制作急性心肌缺血模型:冠状动脉左前降支完全闭塞45min,松开结扎圈再灌注2h。依据美蓝、ttc组织染色,观察各实验组mi质量比、肌钙蛋白t、心肌酶的变化。结果:u50488h可模拟rpc对心肌的保护作用,较对照组明显减少心肌缺血-再灌注损伤所致的mi[(0.15±0.11)g∶(0.29±0.11)g],肌钙蛋白t[冠脉阻闭45min(3.86±1.19)n
3、g/ml∶(9.16±2.82)ng/ml],心肌酶的含量,p均<0.01。该作用可被选择性k阿片受体阻断剂nor-bni所阻断。结论:rpc诱导心肌缺血耐受与k阿片受体激活具有密切关系,激活k阿片受体是rpc诱导心肌缺血耐受的机制之一。.【关键词】缺血预处理;心肌缺血;肌钙蛋白teffectofactivatedk-opioidreceptorandremotepreconditioningonmyocardiumischemiatoleranceentofanesthesiology,qigeneralhospital,lanzhoumilitarydistrict
4、,qi,xnjiang,830000,chinaabstract:objective:tostudytheeffectsofu50488h(aselectivekopioidreceptoragonist)onthesizeofmyocardialischemicreperfusionandtheplasmacontentsofmyocardiumenzymeparedoteischemicpreconditioningfrommyocardialischemiainrabbits.methods:atotalof32malenelydividedintofourgrou
5、ps:remotepreconditioninggroup(rpc),ischemiareperfusiongroup(control),u50488hgroupandkopioidreceptorblockingagent(nor-bni)+u50488hgrouprespectively.thedetailedexperimentalprotocolsalsincontrolgroupinbypentobarbitalsodium(sp)30mg/g,alsinrpcgroupg/gi.vandreceivedbothhindlimbischemiaprecondi
6、tioning2timesmhgfor10minininterval,thenfolloinreperfusion;inu50488hgroup,allanimalsg/gbeforemyocardialischemia,thenstepasrpcgroup.in(nor-bni)+u50488hgroupallanimalsg/kgbeforemyocardialischmemia,thenstepasu50488hgroup.themodelofmyocardialischmemiaadeintheendofeachgroup.leftanteriordescending
7、coronaryarteryinandfolloinedbystainingethyleneblueandtriphenyltetrazoliumchloride(ttc)respectively.results:paredtroponint[(9.16±2.82)ng/mlvs.(3.86±1.19)ng/ml](p<0.01all)andmyocardiumenzymecausedbymyocardialischemiareperfusioninjury(p<0.05all),entan
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