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时间:2020-05-24
《非酒精性脂肪肝与2型糖尿病肾损伤关系的研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·10·医药论坛杂志2014年1月第35卷第1期JMedicalForumVo1.35No.1January2014非酒精性脂肪肝与2型糖尿病肾损伤关系的研究商慧鲜,李华,杨再刚,李天艺郑州大学第一附属医院老年内分泌科,郑州450052摘要:目的探讨非酒精性脂肪肝(NAFLD)与2糖尿病肾损伤发生风险之间的关系。方法T2DM患者466例,分为T2DM伴NAFLD组(N组,n=266)及T2DM不伴NAFLD组(NN组,n:200),测定24h尿微量白蛋白排泄率(UAER),比较两组间肾脏损伤发生率。结果N组BMI
2、、DBP、FPG、FCP、FINS、HbA1c、HOMA—IR、TC、TG、ALT、UAER高于NN组(P<0.05);N组的肾损伤发生率高于NN组(P<0.05);Logistic回归分析显示,NAFLD是2糖尿病肾损伤的独立危险因素(P3、ciationsbetweennonalcoholicfattyliverdiseaseandrenalinjuryinpatientswithtype2diabetesSHANGHui—xian,LIHua,YANGZai—gang,LITian—yiDepartmentofEndocrinologyingerontology,theFirstAfiliatedHospitalofZhengzhouUniversity,Zhengzhou450052,ChinaAbstract:ObjectiveToinves4、tigatetheassociationsbetweennon—alcoholicfattyliverdisease(NAFLD)andrenalin·juryinacohortoftype2diabeticindividuals.MethodsFourhundredandsixty—sixpatientswereinvestigatedrespectively.Prevalencesofrenalinjuryinpatientswithtype2diabeteswereassessedin466type2dia5、beticpatients,whoweredividedintotwogroupsbythepresenceofNAFLD.T2DMwithNAFLDgroup(Ngroup,n=266)andT2DMwithoutNAFLDgroup(NNgroup,n=200).Theincidenceofrenaldatnageinpatientswithtype2diabeteswasassessedbytestingthe24hurinaryalbuminexcretionrate(UAER).ResultsCompa6、redwithdiabeticpatientswithoutNAFLD,thepa—tientswithNAFLDhadsignificantlyhigherBMI,DBP,FPG,FCP,FINS,HbA1c,HOMA—IR,TC,TG,ALT,UAER(P<0.05).NgrouppatientshadremarkablyhigherrenalinjuryprevalencethantheircounterPartsNNgroup(P<0.05).Inmultivariatelogisticregressio7、nanalysis,NAFLDwasindependentlyassociatedwithprevalentofrenalinjuryinpatientswithtype2diabetes(P<0.05).TheseassociationswereindependentofSBP,DBP,TC,TG,HDL—C.ConclusionTheincidencesofrenalinjuryinpatientswithtype2diabete~weresignificantlyhigherinthepatientswit8、hNAFLDthanthosewithoutNAFLD.OurfindingssuggestthatNAFLDisindependentlyofseveralconfoundingfactors,withahigherprevalenceofrenalinjuryintype2diabeticindividuals.Keywords:Type2diabetesmellit
3、ciationsbetweennonalcoholicfattyliverdiseaseandrenalinjuryinpatientswithtype2diabetesSHANGHui—xian,LIHua,YANGZai—gang,LITian—yiDepartmentofEndocrinologyingerontology,theFirstAfiliatedHospitalofZhengzhouUniversity,Zhengzhou450052,ChinaAbstract:ObjectiveToinves
4、tigatetheassociationsbetweennon—alcoholicfattyliverdisease(NAFLD)andrenalin·juryinacohortoftype2diabeticindividuals.MethodsFourhundredandsixty—sixpatientswereinvestigatedrespectively.Prevalencesofrenalinjuryinpatientswithtype2diabeteswereassessedin466type2dia
5、beticpatients,whoweredividedintotwogroupsbythepresenceofNAFLD.T2DMwithNAFLDgroup(Ngroup,n=266)andT2DMwithoutNAFLDgroup(NNgroup,n=200).Theincidenceofrenaldatnageinpatientswithtype2diabeteswasassessedbytestingthe24hurinaryalbuminexcretionrate(UAER).ResultsCompa
6、redwithdiabeticpatientswithoutNAFLD,thepa—tientswithNAFLDhadsignificantlyhigherBMI,DBP,FPG,FCP,FINS,HbA1c,HOMA—IR,TC,TG,ALT,UAER(P<0.05).NgrouppatientshadremarkablyhigherrenalinjuryprevalencethantheircounterPartsNNgroup(P<0.05).Inmultivariatelogisticregressio
7、nanalysis,NAFLDwasindependentlyassociatedwithprevalentofrenalinjuryinpatientswithtype2diabetes(P<0.05).TheseassociationswereindependentofSBP,DBP,TC,TG,HDL—C.ConclusionTheincidencesofrenalinjuryinpatientswithtype2diabete~weresignificantlyhigherinthepatientswit
8、hNAFLDthanthosewithoutNAFLD.OurfindingssuggestthatNAFLDisindependentlyofseveralconfoundingfactors,withahigherprevalenceofrenalinjuryintype2diabeticindividuals.Keywords:Type2diabetesmellit
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