欢迎来到天天文库
浏览记录
ID:55605660
大小:940.60 KB
页数:4页
时间:2020-05-20
《食管癌术前同步多西他赛联合顺铂化放疗的临床观察-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中华肿瘤防治杂志2012年5月第19卷第9期CHINJCANCERPREVTREAT,May2012,Vo1.19No.9《临床应用研究/论著l食管癌术前同步多西他赛联合顺铂化放疗的临床观察丁颖,苏琼菲,杨帆,刘晓清,彭苗,莫凯岚,王希成广东药学院附属第一医院肿瘤科,广东广州510080【摘要】目的:探讨多西他赛联合顺铂术前同步放化疗治疗食管癌的疗效。方法:对22例食管癌初治患者采用术前同步放化疗。放疗采用三维适形放疗技术(3DCRT),处方剂量46Gy/23次,在放疗的第1和4周均给予多西他赛和顺铂化疗2个周期。放化疗结束后休息4~6周,行食管癌根治术
2、。结果:22例患者完成术前放化疗,术前放化疗的临床有效率为81.8(18/22)。21例患者进一步接受手术,根治性切除率为95.2,病理完全缓解率为38.1(8/21)。与治疗前分期比较,T与N分期均明显提前,P值均3、食管癌可取得较高的临床有效率和完全病理缓解率,明显降低食管癌的分期,有望提高局部中晚期食管癌的生存率。本治疗方案,患者耐受性良好,无治疗相关性的死亡。中华肿瘤防治杂志,2012,l9(9):679—682【关键词】食管肿瘤;放射疗法;药物疗法;外科手术Cinicalstudyofdocetaxolcombinedwithcisplatininneo--adjuvantchemo·-radiotherapyforesophagealcarcinomaDINGYing,SUQiong—fei,YANGFan,L儿Xiao—qing,PENGMiao,MOKa4、i—lan,WANGXi—chengDepartmentOfOncology,FirstAffiliatedHospitalofOuangdongCollegeofPharmacy,C-uangzhou510080,P.R.China~ABSTRACT]OBJECTIVE:Toinvestigatetheprognosisofesophagealcarcinomareceivingdocetaxolcombinedwithcis—platininneo—adjuvantchemo—radiotherapyfollowedbysurgery.METHODS5、:Twenty—twopatientswithprimarydiagnosisofesophagealcarcinomawereintothisstudy.Theradiotherapyusedthreedimensionalconformalradiotherapyandtheprescribeddosewas46Gy/23F.Thechemotherapyconsistedofdocetaxolandcisplatin.Thechemotherapywasadminis—teredincontinuousinfusionforthefirstweek6、andthefourthweek.Aftercompletionofchemo—radiotherapy,clinicalrestagingwasperformed.Esophagectomyandlymphadenectomieswereperformed4—6weeksafterchemo—radiotherapy.RESULTS:Twenty-twopatientsfinishedthepreoperativechemo—radiotherapy.Theclinicalresponserateofchemo—radio—therapywas81.87、(18/22).Twenty-onecasescontinuedtoreceivedesophagectomy,therateofradicalresectionwas95.2andthepathologicalcompleteresponseratewas38.1(8/21).TheTandNweredownstagedcomparedtothepre—treatment。.Toxicitygrade3—4includedleucopenia,vomitingandradiationesophagitis.Surgery—relatedcomplica8、—tionsincludedpulmonaryinfection(4.8,1/2
3、食管癌可取得较高的临床有效率和完全病理缓解率,明显降低食管癌的分期,有望提高局部中晚期食管癌的生存率。本治疗方案,患者耐受性良好,无治疗相关性的死亡。中华肿瘤防治杂志,2012,l9(9):679—682【关键词】食管肿瘤;放射疗法;药物疗法;外科手术Cinicalstudyofdocetaxolcombinedwithcisplatininneo--adjuvantchemo·-radiotherapyforesophagealcarcinomaDINGYing,SUQiong—fei,YANGFan,L儿Xiao—qing,PENGMiao,MOKa
4、i—lan,WANGXi—chengDepartmentOfOncology,FirstAffiliatedHospitalofOuangdongCollegeofPharmacy,C-uangzhou510080,P.R.China~ABSTRACT]OBJECTIVE:Toinvestigatetheprognosisofesophagealcarcinomareceivingdocetaxolcombinedwithcis—platininneo—adjuvantchemo—radiotherapyfollowedbysurgery.METHODS
5、:Twenty—twopatientswithprimarydiagnosisofesophagealcarcinomawereintothisstudy.Theradiotherapyusedthreedimensionalconformalradiotherapyandtheprescribeddosewas46Gy/23F.Thechemotherapyconsistedofdocetaxolandcisplatin.Thechemotherapywasadminis—teredincontinuousinfusionforthefirstweek
6、andthefourthweek.Aftercompletionofchemo—radiotherapy,clinicalrestagingwasperformed.Esophagectomyandlymphadenectomieswereperformed4—6weeksafterchemo—radiotherapy.RESULTS:Twenty-twopatientsfinishedthepreoperativechemo—radiotherapy.Theclinicalresponserateofchemo—radio—therapywas81.8
7、(18/22).Twenty-onecasescontinuedtoreceivedesophagectomy,therateofradicalresectionwas95.2andthepathologicalcompleteresponseratewas38.1(8/21).TheTandNweredownstagedcomparedtothepre—treatment。.Toxicitygrade3—4includedleucopenia,vomitingandradiationesophagitis.Surgery—relatedcomplica
8、—tionsincludedpulmonaryinfection(4.8,1/2
此文档下载收益归作者所有