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《细胞毒性T淋巴细胞相关抗原-4基因多态性与Graves病复发的相关性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、14JBengbuMedCoil,January2015,Vo1.40,No.1[文章编号]1000-2200(2015)01-0014-03·基础医学·细胞毒性T淋巴细胞相关抗原4基因多态性与Graves病复发的相关性研究查秀婧,毕娅欣[摘要]目的:探讨细胞毒性T淋巴细胞相关抗原(CTLA)-4基因多态性与Graves病(GD)复发的相关性。方法:选择102例GD复发患者(A组60例为停药3年内复发60例,B组为3年后复发42例)、4O例GD初发患者和8O名健康人群(正常对照组),应用聚合酶链反应一限制性内切酶片段长度多态技
2、术进行CTLA-4基因外显子1第17密码子49位点A/G多态性检测。结果:CTLA一4基因第一外显子49位点基因型及等位基因的频率分布显示,GD初发组患者GG基因型频率及G等位基因频率均高于正常对照组(P<0.01)。GD复发A组GG基因型频率均高于B组和初发组(P<0.01),B组GG基因型频率高于GD初发组(P<0.01)。结论:CTLA-4基因外显子1第17密码子49位点A/G多态性与GD的发生存在相关性,该位点GG基因型可能是GD患者对抗甲状腺药物疗效差及早期复发的原因。[关键词】Graves病;细胞毒性T淋巴细胞相关
3、抗原4;复发;基因多态性[中图法分类号]R581.1[文献标志码]ADoI:10.13898/j.cnki.issn.1000-2200.2015.01.005ThecorrelationofthepolymorphismofcytotoxicTlymphocyteassociatedantigen-4geneandrecurrenceofGravesdiseaseZHAXiu-jing,BIYa—xin(j.DepartmentofEndocrinology,TheSecondAffiliatedHospitalofBeng
4、buMedicalCollege,BengbuAnhui233040;2.DepartmentofEndocrinology,TheFirstAfiliatedHospitalofBengbuMedicalCollege,BengbuAnhui233004,China)[Abstract]Objective:ToexplorethecorrelationofthepolymorphismofcytotoxicTlymphocyteassociatedantigen-4(cTLA_4)geneandrecurenceofGrav
5、es’disease(GD).Methods:TheA/GpolymorphismsofCTLA_4geneexonseventeenthcodon49locusin102patientswithGDrecurence,whoincluded60recurrencecaseswithin3yearsofwithdrawaldrug(Agroup)and42recurencecasesafter3yearsofwithdrawaldrug(Bgroup),40primaryGDpatients(primarygroup)and8
6、0healthypeople(normalcontrolgroup)weredetectedusingpolymerasechainreactionrestrictionfragmentlen~hpolymorphism.Results:ThefrequencydistributionofgenotypeandalleleinCTLA-4geneexon1of49locusshowedthatthefrequencyofGGgenotypeandGalleleinprimaryGDpatientswerehigherthant
7、hoseinnormalcontrolgroup(P<0.O1),thefrequencyofGGgenotypeinAgroupwashigherthanthatinBgroupandprima~group(P<0.O1),andthefrequencyofGGgenotypeinBgroupwashigherthanthatinprima~group(P<0.01).Conclusions:TheA/GpolymorphismofCTLA-4geneexonseventeenthcodon49locusisrelatedt
8、otheGDoccurrence,theGGgenotypeofwhichmaybethereasonofthepooreffectofantithyroiddrugsandearlyrecurenceinGDpatients.[Keywords]Gravesdisease;
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