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时间:2020-05-14
《焦虑抑郁对不孕症患者体外受精-胚胎移植治疗的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、224NeuralIniuryAndFunctionalReconstruction,Mav2015,Vo1.10.No.3·论著·焦虑抑郁对不孕症患者体外受精.胚胎移植治疗的影响彭芳,姚丽华b,刘忠纯作者单位摘要目的:了解焦虑、抑郁对不孕症患者体外受精.胚胎移植(IVE.ET)治疗的影响。方法:纳入不孕症患者武汉大学人民医院242例,在IⅦ-ET过程的不同时间点采用抑郁自评量表(SDS)和焦虑自评量表(SAS)对患者进行测评,按其&生殖医学中心,b.焦虑及抑郁程度分为轻度组与中度组,比较2组患者体外受精、胚胎移植情况,并分析负性情绪对
2、IvF.ET治精神卫生中心疗结果的影响。结果:最终224例患者完成调查,纳入轻度组138例,中度组86例;轻度组体外胚胎正常发武汉430000育、胚胎遗传筛查结果正常及足月产的比例及受精率均显著高于中度组(P<0.05);轻度组胎盘异常发生率及基金项目流产率低于中度组(P<0.05);多因素Logistic回归分析结果显示:抑郁、焦虑、整体负面情绪是影响IvF.ET治疗结果的独立危险因素(P<0.05)。结论:焦虑、抑郁对IVF.ET的成功率有显著的负面影响。国家自然科学基金关键词不孕症;体外受精.胚胎移植;抑郁;焦虑(No.30971
3、040;No.中图分类号R741;R749.92文献标识码ADOI10.3870/sjsscj.2015.03.01281271496)“十二五计划”项目EffectsofAnxietyandDepression011theSuccessRateof/11VitroFertilizationandEmbryo课题TransferTreatmentforInfertilityPatientsPENGFang,YAOLi-hua,LIUZhong-chun,Reproductive(No.2O12BAIO1BMe~cmeCenter,Ren
4、minHospitalofWuhanUniversity,Wuhan430060,China05)AbstractObjective:Toanalyzetheefectsofanxietyanddepressiononthesuccessrateof面vitrofertilization收稿日期andemb~otmns~r(rw—ET)treatmentforinfertilitypatients.Methods:Twohundredandforty·twocaseswithin—2O15.O4.06fertilitywereenrol
5、led.Self-ratingdepressionscale(SDS)andself-ratinganxietyscale(SAS)wereusedtoevaluatepmiems’negativeemotionsduringtheprocessofⅣF—ET.Patientsweredividedintomildormoderategroupac—通讯作者cordingtotheirscoresofSDSandSAS./nvitrofertilizationSuccessrateandemb~osurvivalinthematerna
6、luteri刘忠纯werecomparedandtheimpactofnegativeemotionsonⅣF—ETwasanalyzed.Results:Therateofsuccessfulfer-zcliu6@whu.edu.cntilization,normaldevelopmentoftheemb~o/nvitro,normalemb~ogeneticscreeningresultsaswellasfull—termpregnancyweresignificantlyhi曲erinthemildgroupthanthosein
7、moderategroup(P<0.05).Therateofplacentalabnormalitiesandabortionweresignificantlylowerinthemildgroupthanthoseinthemoderategroup(P<0.05).Logisticregressionanalysisshoweddepression(SDSindex),anxiety(SASindex),theoverallnegativeemotions(SDS+SAS)wereindependentriskfactorsfor
8、theIVF-ETtreatmentresultsfP<0.05).Conclusion:Anxietyandde—pressionhaveasignificantnegativeimpactonthesu
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