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时间:2020-05-01
《不同麻醉深度对老年肠癌手术患者应激反应的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·694·doi10.3969~.issn.1673—4254.2014.05.21JSouthMedUniv,2014,34(5):694·698l备床研究不同麻醉深度对老年肠癌手术患者应激反应的影响田可耘,康茵,邓龙姣,刘红,李海风,王志鹏,赵国栋广东省人民医院//广东省医学科学院麻醉科,广东广州510080摘要:目的探讨Narcotrend~lJ下3种不同麻醉深度对老年肠癌手术患者应激反应的影响。方法全身麻醉下行腹腔镜辅助下肠癌根治术的老年患者105例,60岁~91岁,ASAI~Ⅲ级,随机均分为3组(n=35):A组(麻醉深度维持Narcotrend指数即NI在D。水平),
2、B组(NI在D)和c组(NI在E)。术中根据Narcotrend监测结果调整麻醉用药使各组麻醉深度维持在预设定目标水平。记录患者麻醉诱导前(T。)、气管插管前(T。)、气管插管后即刻(T:)、气腹前2min(T,)、气腹后2min(T)、手术结束(Ts)和拔管时(T)的心率(HR)和平均动脉压(MAP)。检测患者麻醉前(Ta)、术毕()和术后第1天()的血清皮质醇(Cor)、促肾上腺皮质激素(ACTH)、血管内皮素(ET-])、肿瘤坏死因子(1NF.a)、白介素.6(IL一6)和c反应蛋白(CRP)水平。结果与麻醉诱导前比较,A组患者心率(HR)和平均动脉压(MAP)在气管插管后
3、即刻、气腹后2min、拔管时明显增加(P<0.05),且明显高于B组和C组(P4、升高(P<0.05),且高于c组(.P<0.O1);c组ET-1在术毕和术后第1天明显低于A组和B组(P<0.05或P5、GLongjiao,LIUHong,LIHaifeng,WANGZhipeng,ZHAOGuodongDepartmentofAnesthesiology,GuangdongGeneralHospital,GuangdongAcademyofMedicalScience,Guangzhou510080,ChinaAbstract:ObjectiveToinvestigatetheeffectsofdifferentanesthesiadepthonstressresponseinelderlypatientsundergoingelectivelaparoscopicsurger6、yforcolorectalcancer.MethodsAtotalof105ASAI-IIIpatientsaged60-91yearsundergoingelectivelaparoscopicsurgeryforcolorectalcancerwithgeneralanesthesiawererandomizedinto3groups,namelygroupAwithatargetNarcotrendindex(NI)maintainedatD01evel,groupBwi出aNIatD2level,andgroupCwi出aNIatE1leve1.Theanestheti7、cs(profopolandremifentanil)wereadjustedaccordingtoNarcotrendmonitoringresultstomaintainthespecifiedanesthesiadepth.Thepatients’heartrate(HR)andmeanarterypressure(MAP)wererecordedbeforeanesthesia(T0),beforeintubation(T1),immediatelyafterintuba
4、升高(P<0.05),且高于c组(.P<0.O1);c组ET-1在术毕和术后第1天明显低于A组和B组(P<0.05或P5、GLongjiao,LIUHong,LIHaifeng,WANGZhipeng,ZHAOGuodongDepartmentofAnesthesiology,GuangdongGeneralHospital,GuangdongAcademyofMedicalScience,Guangzhou510080,ChinaAbstract:ObjectiveToinvestigatetheeffectsofdifferentanesthesiadepthonstressresponseinelderlypatientsundergoingelectivelaparoscopicsurger6、yforcolorectalcancer.MethodsAtotalof105ASAI-IIIpatientsaged60-91yearsundergoingelectivelaparoscopicsurgeryforcolorectalcancerwithgeneralanesthesiawererandomizedinto3groups,namelygroupAwithatargetNarcotrendindex(NI)maintainedatD01evel,groupBwi出aNIatD2level,andgroupCwi出aNIatE1leve1.Theanestheti7、cs(profopolandremifentanil)wereadjustedaccordingtoNarcotrendmonitoringresultstomaintainthespecifiedanesthesiadepth.Thepatients’heartrate(HR)andmeanarterypressure(MAP)wererecordedbeforeanesthesia(T0),beforeintubation(T1),immediatelyafterintuba
5、GLongjiao,LIUHong,LIHaifeng,WANGZhipeng,ZHAOGuodongDepartmentofAnesthesiology,GuangdongGeneralHospital,GuangdongAcademyofMedicalScience,Guangzhou510080,ChinaAbstract:ObjectiveToinvestigatetheeffectsofdifferentanesthesiadepthonstressresponseinelderlypatientsundergoingelectivelaparoscopicsurger
6、yforcolorectalcancer.MethodsAtotalof105ASAI-IIIpatientsaged60-91yearsundergoingelectivelaparoscopicsurgeryforcolorectalcancerwithgeneralanesthesiawererandomizedinto3groups,namelygroupAwithatargetNarcotrendindex(NI)maintainedatD01evel,groupBwi出aNIatD2level,andgroupCwi出aNIatE1leve1.Theanestheti
7、cs(profopolandremifentanil)wereadjustedaccordingtoNarcotrendmonitoringresultstomaintainthespecifiedanesthesiadepth.Thepatients’heartrate(HR)andmeanarterypressure(MAP)wererecordedbeforeanesthesia(T0),beforeintubation(T1),immediatelyafterintuba
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