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《伊立替康联合顺铂治疗进展期食管鳞癌的疗效观察.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·1669··短篇论著·伊立替康联合顺铂治疗进展期食管鳞癌的疗效观察宋敏,李磊,常志伟,薄志广,常志军,杨广义,王静,畅捷【摘要】目的观察伊立替康联合顺铂治疗进展期食管鳞癌的疗效。方法2007—05—20-2009—05—20共入组进展期食管鳞癌患者46例,采用伊立替康75mg/m,持续静脉滴注90min,第1、8天;顺铂25mg/m2,静脉滴注,第1—3天;21d为1个周期;至少完成2个周期化疗者方可评价疗效。结果本组46例患者共完成188个化疗周期,在可评价疗效的45例患者中,完全缓解5例,部分缓解16例,稳定13例,进展11例,
2、有效率为46.7%(21/45),疾病控制率为75.6%(34/45);1年生存率为20.O%(9/45),中位疾病进展时间为5.0个月[95%CI(3.9,6.1)],中位生存时间为9.0个月[95%c,(8.3,9.7)];化疗主要毒副作用为腹泻、脱发、恶心、血小板减少、粒细胞减少、呕吐等。结论伊立替康联合顺铂治疗进展期食管鳞癌疗效确切,安全性及患者依从性好,可作为进展期食管鳞癌的治疗方案。【关键词】伊立替康;顺铂;食管肿瘤;抗肿瘤联合化疗方案【中图分类号】R735.1【文献标识码】Bdoi:10.3969/j.issn.1007
3、—9572.2013.05.067宋敏,李磊,常志伟,等.伊立替康联合顺铂治疗进展期食管鳞癌的疗效观察[J].中国全科医学,2013,16(5):1669—1671.[www.chinagp.net]IrinotecanCombinedthCisplatininAdvancedEsophagealSquamousCellCarcinomaSONGMin,LILei,CHANGZhi—wei,eta1.DepartmentofOncology,therstAfiliatedHospitalofZhengzhouUniversity,Zh
4、engzhou450052,China【Abstract】ObjectiveToinvestigatetheefficacyandtoxicityofirinotecancombinedwithcisplatinintreatmentforpa—tientswithadvancedesophagealsquamouscellcarcinoma.MethodsAtotalof46patientswithadvancedesophagealsqumouscellcarcinomaadmittedfromMay2007toMay2009we
5、regivenirinotecan,75mg/m,ivgttfor90min,ondays1,8,andeisplatin25mg/m,ivgtt,onday1—3.Onecyclelasted21d.Theefectwasevaluatedatleastafter2cycles.ResultsThisgroupofpatientscompletedaltogether188cycles.In45patientswhoseeffectswereevaluable,5remittedcompletely,16partly,13hadst
6、ablecondition,11hadprogression,theeffectiveratewas46.7%(21/45),diseasecontrolratewas75.6%(34/45),1一yearsurvivalratewas20.O%(9/45),medianprogressivetimewas5.0months[95%C/(3.9,6.1)],me—diansurvivaltimewas9.0months[95%C/(8.3,9.7)].Themaintoxicityofchemotherapywerediarrhea,
7、hairloss,nause-a,thrombocytopenia,neutropenia,vomiting.ConclusionTheeffectivenessofifinotecancombinedwitheisplatintreatingad—vancedesophagealsqumouscellcarcinomaisdefinitewithgoodsafetyandpatientscompliance,whichcanbeusedastreatmentprogramsforadvancedesophagealsquamousc
8、ellcarcinoma.【Keywords】Irinotecan;Ciaplatin;Esophagealneoplasms;Antineoplasticcombinedchemotherapyprotocols食管癌
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