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时间:2020-04-17
《不同通气方式联合肺表面活性物质治疗新生儿呼吸窘迫综合征的效果评价.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·临床研究·中国当代医药2014年9月第21卷第25期不同通气方式联合肺表面活性物质治疗新生儿呼吸窘迫综合征的效果评价叶春华张路高波长沙市妇幼保健院儿科,长沙410000【摘要】目的探讨不同通气方式联合肺表面活性物质治疗新生儿呼吸窘迫综合征的有效性及临床价值。方法选择本院2010年1月~2013年1月收治入院的呼吸窘迫综合征新生儿230例,随机分为观察组和对照组各115例,观察组采用鼻塞持续气道正压通气结合肺表面活性物质治疗,对照组采用常规机械通气结合肺表面活性物质治疗,比较两组患儿的临床治疗效果及不良
2、反应情况。结果观察组应用肺表面活性物质后2~3h皮肤颜色转红,经皮血氧饱和度逐渐升高。6h后动脉血氧分压(PaO:)、动脉/肺泡血氧分压比值(a/APO)明显上升,氧合指数(0I)逐渐降低,与治疗前比较,差异有统计学意义(P<0.05);治疗后两组间PaO:、以PO、OI比较,差异有统计学意义(P3、计学意义(P>0.05)。结论鼻塞持续气道正压通气结合肺表面活性物质能有效改善新生儿呼吸窘迫综合征患儿肺顺应性及氧合功能.降低不良反应发生率,适合在临床上推广应用。【关键词】鼻塞持续气道正压通气;肺表面活性剂;新生儿呼吸窘迫综合征【中图分类号】R722.1【文献标识码】A【文章编号】1674-4721(2014)09(a)一0066—03Efectevaluationofdiferentmodesofventilationcombinedwithpu1.monarysurfactantintreatme4、ntofneonatalrespiratorydistresssyndromeyECMn—huaANGLuGA0BoDepartmentofPediatric,MaternalandChildHealthHospitalinChangshaCity,Changsha410000,China【Abstract】0bjectiveToinvestigatetheeffectiveandclinicalvalueofdifierentmodesofventilationcombinedwithpulmonar5、ysurfactantinthetreatmentofneonatalrespiratorydistresssyndrome(NRDS).Methods230casesofneonatalrespiratorydistresssyndromeinourhospitalfromJanuary2010toJanuary2013wereselected,andwererandomlydi—videdintoobservationgroupandcontrolgroup,115casesineachgroup,6、theobservationgroupweretreatedwithnasalcontinuouspositiveairwaypressureventilationcombinedwithpulmonarysurfactanttreatment,thecontrolgroupweretreatedwithconventionalmechanicalventilationtherapycombinedwithpulmonarysurfactant,andtheclinicaltherapeu—ticeff7、ectandadversereactionswerecomparedbetweenthetwogroups.ResultsIntheobservationgroup,aftertheap-plicationofpulmonarysurfactant2to3hours,skincolorchangedtored,transcutaneousoxygensaturationincreasedgradually,after6hours,arterialpartialpressureofoxygen(PaO2)8、,arterial/alveolaroxygenpartialpressureratio(a/AP02)wereincreasedsignificantly,andtheoxygenationindex(OI)wasdecreased,therewassignificantdifferencecon—paredwiththatbeforetreatmentCP<0.05);andthetwogroupshadsignificantdiffe
3、计学意义(P>0.05)。结论鼻塞持续气道正压通气结合肺表面活性物质能有效改善新生儿呼吸窘迫综合征患儿肺顺应性及氧合功能.降低不良反应发生率,适合在临床上推广应用。【关键词】鼻塞持续气道正压通气;肺表面活性剂;新生儿呼吸窘迫综合征【中图分类号】R722.1【文献标识码】A【文章编号】1674-4721(2014)09(a)一0066—03Efectevaluationofdiferentmodesofventilationcombinedwithpu1.monarysurfactantintreatme
4、ntofneonatalrespiratorydistresssyndromeyECMn—huaANGLuGA0BoDepartmentofPediatric,MaternalandChildHealthHospitalinChangshaCity,Changsha410000,China【Abstract】0bjectiveToinvestigatetheeffectiveandclinicalvalueofdifierentmodesofventilationcombinedwithpulmonar
5、ysurfactantinthetreatmentofneonatalrespiratorydistresssyndrome(NRDS).Methods230casesofneonatalrespiratorydistresssyndromeinourhospitalfromJanuary2010toJanuary2013wereselected,andwererandomlydi—videdintoobservationgroupandcontrolgroup,115casesineachgroup,
6、theobservationgroupweretreatedwithnasalcontinuouspositiveairwaypressureventilationcombinedwithpulmonarysurfactanttreatment,thecontrolgroupweretreatedwithconventionalmechanicalventilationtherapycombinedwithpulmonarysurfactant,andtheclinicaltherapeu—ticeff
7、ectandadversereactionswerecomparedbetweenthetwogroups.ResultsIntheobservationgroup,aftertheap-plicationofpulmonarysurfactant2to3hours,skincolorchangedtored,transcutaneousoxygensaturationincreasedgradually,after6hours,arterialpartialpressureofoxygen(PaO2)
8、,arterial/alveolaroxygenpartialpressureratio(a/AP02)wereincreasedsignificantly,andtheoxygenationindex(OI)wasdecreased,therewassignificantdifferencecon—paredwiththatbeforetreatmentCP<0.05);andthetwogroupshadsignificantdiffe
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