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1、JournalofNeuroVirology(1997)3,71-7501997StocktonPressAilrightsreserved1355-0284/97$1200ShortCommunicationFurtherobservationsoncoronavirusinfectionofprimateCNSRonaldSMurray’.‘,Guang-YunCai4,KennethFSoike3andGaryFCabi~ac*,~*ColoradoMultipleSclerosisCenter,Englewood,Colorado,80110;‘NationalJewishCent
2、erforImmunologyandRespiratoryMedicine,Denver,Colorado80262;3TulaneRegionalPrimateResearchCenter,Covington,Louisiana70433;4RockyMountainMSCenter,Englewood,CO80110;and5DepartmentofBiochemistry,BiophysicsandGenetics,UniversityofColoradoHealthSciencesCenter,Denver,Colorado80262,USAPreviouslywedemonstr
3、atedthatintracerebral(IC)inoculationofamurinecoronavirus,MHV-JHM,intotwospeciesofprimatescanresultinacuteencephalomyelitis(Murrayetal.,1992a).Infectiousvirusisolatedfromacutelyinfectedanimals,designatedJHM-OMpl,wasinoculatedICintoasecondgroupofmonkeys.Inthisreportwedescribeobservationsontheacutely
4、infectedanimalsandthosesurvivingtheacuteinfectionthatweresacrificedatlatertimespost-infection.Resultsfromdualinsituhybridizatiodimmunohis-tochemistryscreeningoftissuesshowthatastrocytesaretargetcellsinwhitematterlesionsduringacuteinfection.Inanimalssacrificed150dayspost-infection,areasofdemyelinat
5、edglioticlesions,prominentinthespinalcord,wereseenthroughouttheneuraxis.Novirusproductsweredetectedintheselate-infectionlesions.Keywords:braindisease;demyelinatingdisease;virusdisease;astrocytesForpersonaluseonly.Coronavirusinfectioninrodentsiswidelyusedasaingsuggestedthatmurine-likevirusesarecapa
6、blemodelforstudyingvirusinducedCNSdemyelina-ofinfectingthehumanCNS(Murrayetd.,1992b).tion.SpeculationontheroleofcoronavirusesandInaddition,wereportedthatMHVstrainJHMandothervirusesinhumandemyelinatingdiseasessuchoneoftheputativehumanCNScoronavirusisolatesasmultiplesclerosis(MS)hasexistedformanycou
7、ldreplicate,disseminateandproduceacuteyears.However,coronaviruseshaveneverbeenCNSdiseaseintwospeciesofprimatesfollowingshowntocauseCNSdiseaseinhuman.In1980ICinoculation(Murrayetd.,1992a).therewasareportofcoronavi
