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ID:39119568
大小:2.56 MB
页数:97页
时间:2019-06-25
《多糖衍生物手性固定相分离对映体分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、浙江工业大学硕士学位论文S7rUDYOFENANTIoSEPARATIoNUSINGPoLYSAC.CHARIDEDERI、厂ATIVECH【IiAI,STp汀IONARYPHASEAbstractManyenantiomersofchiralpharmaceuticalsandpesticidesshowdifferentbiologicalactivitiesandtoxicity,SOtheseparationofenantiomersisveryimportant.Theenantioseparati
2、onofseveraltypicalchiralpharmaceuticalsandpesticideswasinvestigatedoncommercialpolysaccharide-derivativechiralstationaryphasesandself-preparedcellulose-derivativechiralstationaryphasesusinghighperformanceliquidchromatography.Infirstpart,usingg,4’一methylened
3、iphenyldiisocyanate鹊bondingspacer,cellulosebenzoate(bonded—CTB)andcellulose3,5一dimethylphenybcarbamate(bonded-CDMPC)werebondedtoaminopropylsilicagelat6-position,thepreparationofbonded-CTBanditsapplicationofenantioseparationhavenotseenliteraturereportatprese
4、nt.Theself-preparedchiralstationaryphaseswerecharacterizedbyFT-IR,andtheenantioseparationofbenzoin,trans-stilbeneoxideandtroger’SbaseWasstudied011self-preparedcolumns,and011bonded—CDMPCgetberetseparation.h1thesecondpart,theherbicidenaproanilideWasseparatedo
5、nChiralcelOD,OJandself-preparedcolumns.TheinfluenceofmobileIII浙江工业大学硕士学位论文phaseadditives,concentrationandtemperatureontheenantioseparationwasstudied,andthetwoself-preparedcolumnscanusewithtetrahydrofuran(THF)asmobilephasemodifier,especiallynaproanilidecange
6、tbaselineseparationonbondedcellulosebenzoate,itCanbeusedforquantitativeanalysisofnaproanilideenantiomers.Inthethirdpart,thechiralseparationof2,3-diaryl一5一chloromethyl一1,3一oxazolidinesand2-(4’一nitro)一aryl,3.aryl.5.chloromethyl-1,3。oxazolidineswasperformedonc
7、hiralcelOD,chiralpakADandChiralpakAS.OnChiralcelOD,thefourisomersof2,3一diaryl-5一chloromethyl一1,3一oxazolidinesgotbaselineseparation,andonChiralpakADthereWaSnoseparationofenantiomers,andonChiralpakAStheenantiomerwereseparated;duetothenitryl,theinteractionbetw
8、een2一(4'-nitro)一aryl,3-aryl一5一chloromethyl一1,3一oxazolidinesandCSPsCanformstrong兀-兀interaction,andonChiralpakADtheretentiontimeWaslongest,andtheelutionsequenceWasalsodifferentfromtheothercolumns.Inthefi
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