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1、第26卷第4期西安交通大学学报(医学版)Vol.26No.42005年8月JournalofXi'anJiaotongUniversity(MedicalSciences)Aug.2005MRP和LRP的表达与食管鳞癌临床病理特征的关系李建辉1,2,侯东祥1,郭党学1,王茁1,毛中鹏1,王振江1(1.陕西省人民医院肿瘤科,陕西西安710068;2.西安交通大学第一医院普外科,陕西西安710061)摘要:目的探讨多药耐药相关蛋白(MRP)和肺耐药蛋白(LRP)在食管鳞癌组织中的表达及其与临床病理特征和预后的关系。方法应用E
2、livision二步免疫组织化学法观察51例食管鳞癌组织和18例癌旁正常黏膜组织(距离癌组织>2cm)中MRP和LRP的表达情况。结果食管鳞癌肿瘤大小在5cm以上者LRP阳性表达率显著高于5cm以下者(P<0.05)。癌组织中MRP和LRP阳性率高于癌旁正常组织,有淋巴结转移者MRP和LRP阳性率高于无淋巴结转移者,MRP和LRP阳性者术后3年生存率低于阴性者,但其差异均无统计学意义。MRP和LRP的表达与患者年龄、肿瘤分化程度、浸润深度、临床分期无统计学相关性。MRP和LRP间无显著性相关。结论MRP和LRP不能作为临
3、床判断食管鳞癌恶性程度、是否转移和预测预后的独立指标,但可提示这些蛋白阳性的患者存在易转移和预后差的趋势。关键词:食管癌;MRP;LRP中图分类号:R735.1文献标识码:A文章编号:1671-8259(2005)04-0377-04RelationshipbetweenexpressionofMRP,LRPandclinicalpathologicalfeaturesinesophagealsquamouscellcarcinoma1,2,HouDongxiang1,GuoDangxue1,WangZhuo1,MaoZ
4、hongpeng1,WangZhenjiang1LiJianhui(1.DepartmentofOncology,ShaanxiProvincePeople'sHospital,Xi'an710068;2.DepartmentofGeneralSurgery,FirstHospitalofXi'anJiaotongUniversity,Xi'an710061,China)ABSTRACT:ObjectiveToinvestigatetheexpressionofMRPandLRPinesophagealsquamousc
5、ellcarcinoma(ESCC)tissuesandtherelationshipbetweentheirexpressionandclinicalpathologicalfeaturestogetherwithprognosisofESCC.MethodsElivisionimmunhistochemistrywasusedtodetecttheexpressionofMRPandLRPin51ESCCtissuesand18surroundingnoncanceroustissues(thedistanceisb
6、eyond2cm).ResuItsTherewassignificantcorrelationbetweenLRPexpressionandtumorsize(1<0.05).TheexpressionrateofMRPorLRPintumortissueswashigherthanthatinnormaltissues;thepositiverateofMRPorLRPinESCCwithlymphnodeinvolvementwashigherthanthatwithoutlymphnodemetastasis.Th
7、ethree-yearsurvivalrateofnegativepatientswashigherthanthatofpositivepatients,buttherewasnosignificantdifference.NosignificantcorrelationwasobservedbetweenMRPorLRPexpressionandpatientage,celldifferentiation,invasiondepthandclinicalstaging.Nosignificantcorrelationw
8、asobservedbetweenMRPandLRPexpression.ConcIusionTheexpressionofMRPorLRPcan'tberegardedasanindependentmarkertopredictmalignantdegree,lymphnodeinvolvementandprogn
