尿肝型脂肪酸结合蛋白与iga肾病小管间质损伤的关系

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1、授予单位代码10089学号或申请号20122036HebeiMedicalUniversity硕士学位论文科学学位尿肝型脂肪酸结合蛋白与IgA肾病小管间质损伤的关系研究生：夏薇青导师：裴华颖教授专业：内科学二级学院：第二医院2015年3月河北医科大学学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立完成。本学位论文研宄所获得的研宄成果，其知识产权归河北医科大学所有。河北医科大学有权对本学位论文进行交流、公幵和使用。凡发表与学位论文主要内容相关的论文，第一署名为单位河北医科大学，试验材料、原始数据、申报的专利等知识

2、产权均归河北医科大学所有。否则，承担相应法律责任。,•；...•‘‘../.V'v‘•研宄生签名：戈叛為导师签章二级学院领导盖章:）；20IS年j月Z《日：::河北医科大学研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研宄成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：

3、极导师签章:20

4、>年3月<曰目录中文摘要························································

5、·························1英文摘要·················································································4英文缩写·················································································8研究论文尿肝型脂肪酸结合蛋白与IgA肾病小管间质损伤的关系前言···············································

6、··································9材料与方法········································································9结果···············································································12附图··············································································

7、·15附表···············································································19讨论···············································································23结论···············································································27参考文献····················

8、·····················································27综述肝型脂肪酸结合蛋白在慢性肾脏病中的研究进展···················31致谢·····················································································42个人简历···············································································43中文摘

9、要尿肝型脂肪酸结合蛋白与IgA肾病小管间质损伤的关系摘要目的：观察慢性肾小球肾炎、IgA肾病（IgAnephropathy，IgAN）患者应用ACEI/ARB治疗前后尿肝型脂肪酸结合蛋白（liver-typefattyacidbindingprotein，L-FABP）及氧化应激指标的变化，探讨L-FABP与IgAN小管间质损伤（tubularinterstitiallesion，TIL）的关系。方法：IgAN组：选取2013年6月至2014年2月在我院经临床和肾病理确诊为慢性肾小球肾炎，IgAN患者52例。根据牛津分型中TIL程度将其分为三组：

10、T0组，肾小管萎缩/间质纤维化程度＜25%；T1组，肾小管萎缩/间质纤维化程度25%~50%；T2组，肾小管萎缩/间质纤维化程度>50%