emmprin在涎腺腺样囊性癌嗜神经侵袭中作用及机制的研究

《emmprin在涎腺腺样囊性癌嗜神经侵袭中作用及机制的研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、独独创创性性声声明明秉承学校严谨的学风与优良的科学道德，本人声明所呈交的论文是我个人在导师指导下进行的研究工作及取得的研究成果。尽我所知，除了文中特别加以标注和致谢的地方外，论文中不包含其他人已经发表或撰写过的研究成果，不包含本人或他人已申请学位或其他用途使用过的成果。与我一同工作的同志对本研究所做的任何贡献均已在论文中作了明确的说明并表示了致谢。申请学位论文与资料若有不实之处，本人承担一切相关责任。论文作者签名：日期：保保护护知知识识产产权权声声明明本人完全了解第四军医大学有关保护知识产权的规定，即：研究生在校攻读学位期间论文工作的知识产权单位属第四军医大学。本人保证毕业离校后，发表

2、论文或使用论文工作成果时署名单位仍然为第四军医大学。学校可以公布论文的全部或部分内容（含电子版，保密内容除外），可以采用影印，缩印或其他复制手段保存论文。学校有权允许论文被查阅和借阅，并在校园网上提供论文内容的浏览和下载服务。同意学校将论文加入《中国优秀博硕士学位论文全文数据库》和编入《中国知识资源总库》，同意按《中国优秀博硕士学位论文全文数据库出版章程》规定享受相关权益。论文作者签名：导师签名：日期：EMMPRIN在涎腺腺样囊性癌嗜神经侵袭中的作用及机制研究研究生：杨新杰学科专业：口腔临床医学（颌外）所在单位：第四军医大学口腔医院颌面外科导师：刘宝林教授（主任医师）辅导教师：雷德林教

3、授（主任医师）资助基金项目：第四军医大学博士学位论文课题资助（2010D14）关键词：涎腺腺样囊性癌；肿瘤侵袭；嗜神经侵袭；EMMPRIN；MMPs；RNA干扰中国人民解放军第四军医大学二O一二年五月博士学位论文目录缩略语表·······································································································1中文摘要············································································

4、···························3ABSTRACT··································································································6前言·····································································································10文献回顾····················································

5、·················································11文献回顾一涎腺腺腺样囊性癌嗜神经侵袭的研究进展·························11文献回顾二EMMPRIN在肿瘤中的相关作用研究进展··························17正文·····································································································22第一部分EMMPRIN在涎腺腺样囊性癌的表达及意义············

6、··············221材料与方法·····················································································222结果································································································293讨论···················································································

7、·············33第二部分EMMPRINSIRNA重组慢病毒载体的构建及稳定转染细胞株的的筛选····················································································411材料与方法···············································································