il-iβ诱导下人牙龈成纤维细胞表达egfrr的研究

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1、ߚ㉏ো˖ऩԡҷⷕ˖10114ᆚ㑻˖ᄺো˖200930722IL-1ȕ䇅ᇐϟҎ⠭啜៤㑸㓈㒚㚲㸼䖒EGFRⱘⷨおIL-1¡inductingofEGFRexpressioninHumangingivalfibroblastsⷨお⫳˖䍉᫔ᣛᇐᬭᏜ˖ᴢ䳲ࡃᬭᥜ⬇䇋ᄺԡ䮼㉏㑻߿˖⸩຿ⷨお⫳ϧϮৡ⿄˖ষ㜨Јᑞएᄺⷨおᮍ৥˖ষ㜨ݙ⾥ᄺ᠔೼ᄺ䰶˖ষ㜨एᄺ䰶ѠOϔϝᑈϝ᳜क᮹ᄺԡ䆎᭛⣀߯ᗻໄᯢᴀҎໄᯢˈ᠔ਜѸⱘᄺԡ䆎᭛㋏೼ᇐᏜᣛᇐϟᴀ᭛⣀ゟᅠ៤ⱘⷨお៤ᵰDŽ᭛Ёӏԩᓩ⫼ҪҎⱘ៤ᵰˈഛᏆخߎᯢ⹂ᷛ⊼៪ᕫࠄ䆌ৃDŽ䆎᭛ݙᆍ᳾ࣙ৿⊩ᕟᛣНϞᏆሲѢҪҎⱘӏԩᔶᓣⱘⷨお៤ᵰˈгϡࣙ৿ᴀҎᏆ⫼Ѣ݊Ҫᄺԡ⬇䇋ⱘ䆎᭛៪៤

2、ᵰDŽϢ៥ϔৠᎹ԰ⱘৠᖫᇍᴀⷨお᠔خⱘӏԩ䋵⤂ഛᏆ೼䆎᭛Ё԰њᯢ⹂ⱘ䇈ᯢᑊ㸼⼎䇶ᛣDŽᴀ᭛བ䖱ডϞ䗄ໄᯢˈᜓᛣᡓᢙҹϟ䋷ӏ੠ৢᵰ˖1ǃѸಲᄺ᷵ᥜќⱘᄺԡ䆕к˗2ǃᄺ᷵ৃ೼Ⳍ݇ၦԧϞᇍ԰㗙ᴀҎⱘ㸠Ў䖯㸠䗮᡹˗3ǃᴀ᭛ᣝ✻ᄺ᷵㾘ᅮⱘᮍᓣˈᇍ಴ϡᔧপᕫᄺԡ㒭ᄺ᷵䗴៤ⱘৡ䁝ᤳᆇˈ䖯㸠݀ᓔ䘧ℝDŽ4ǃᴀҎ䋳䋷಴䆎᭛៤ᵰϡᅲѻ⫳ⱘ⊩ᕟ㑴㒋DŽ䆎᭛԰㗙ㅒৡ˖᮹ᳳ˖ᑈ᳜᮹ᄺԡ䆎᭛⠜ᴗՓ⫼ᥜᴗкᴀҎᅠܼњ㾷ቅ㽓ए⾥໻ᄺ᳝݇⬭ǃՓ⫼ᄺԡ䆎᭛ⱘ㾘ᅮˈৠᛣᄺ᷵⬭៪৥೑ᆊ᳝݇䚼䮼៪ᴎᵘ䗕Ѹ䆎᭛ⱘ໡ॄӊ੠⬉ᄤ⠜ˈܕ䆌䆎᭛㹿ᶹ䯙੠׳䯙˗ᴀҎᥜᴗቅ㽓ए⾥໻ᄺৃҹᇚᴀᄺԡ䆎᭛ⱘܼ䚼៪䚼ߚݙᆍ㓪᭄ܹ᳝݇᥂ᑧ䖯㸠Ẕ㋶ˈৃҹ䞛⫼ᕅ

3、ॄǃ㓽ॄ៪݊Ҫ໡ࠊ᠟↉ᄬ䆎᭛੠∛㓪ᴀᄺԡ䆎᭛DŽᴀҎ⾏᷵ৢথ㸼៪Փ⫼ᄺԡ䆎᭛៪Ϣ䆹䆎᭛Ⳉ᥹Ⳍ݇ⱘᄺᴃ䆎᭛៪៤ᵰᯊˈ㕆ৡऩԡҡ✊Ўቅ㽓ए⾥໻ᄺDŽ(ᆚ䆎᭛೼㾷ᆚৢᑨ䙉ᅜℸ㾘ᅮ)䆎᭛԰㗙ㅒৡ˖᮹ᳳ˖ᑈ᳜᮹ᣛᇐᬭᏜㅒৡ˖᮹ᳳ˖ᑈ᳜᮹˄ᴀໄᯢⱘ⠜ᴗᔦቅ㽓ए⾥໻ᄺ᠔᳝,᳾㒣䆌ৃ,ӏԩऩԡঞӏԩϾҎϡᕫ᪙㞾Փ⫼˅Ⳃᔩ㓽⬹䆡.....................................................................................................................................ĘЁ᭛ᨬ㽕...

4、................................................................ę㣅᭛ᨬ㽕.................................................................................................................................ěࠡ㿔..............................................................................................

5、.....................................5㄀ϔ䚼ߚҎ⠭啜៤㑸㓈㒚㚲ॳҷӴҷ෍ݏঞ䡈ᅮ..............................................................7ᅲ偠ᴤ᭭............................................................................................................................7ᅲ偠ᮍ⊩........................................

6、....................................................................................8ᅲ偠㒧ᵰ..........................................................................................................................13䅼䆎................................................................................

7、..........................................15㄀Ѡ䚼ߚIL-1©䇅ᇐϟҎ⠭啜៤㑸㓈㒚㚲㸼䖒EGFRⱘⷨお.............................................17ᅲ偠ᴤ᭭..........................................................................................................