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ID:33923469
大小:4.17 MB
页数:38页
时间:2019-02-28
《术后肠梗阻对大鼠下丘脑和脑干nesfatin-1表达的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、万方数据摘要目的:观察术后肠梗阻对大鼠脑内nesfatin-1表达的影响。方法:大鼠经腹腔注射硫酸仲丁巴比妥(100~150mg/kg)麻醉后行腹部手术,术后2小时后经心灌注固定,免疫组化观察大鼠脑内c-Fos和nesfatin-1免疫阳性神经元的表达。结果:手术组大鼠下丘脑视上核(SON)(岛.9,P2、副核(Ew)CFl0.74,P0.05)。但统计分析发现,腹部手术激活的c.Fos神经元中,在下丘脑SON内99%、apPVN内71%、lrIlPVN内47%、mmPVN内41%以及mpPVN内9%表达nesfatin-1;在脑干,腹部手术可分别激活LC内91%、rRPa内82%、EW和VLM内74%3、、NTS14%表达c-Fos的nesfatin-t神经元。结论:腹部手术可激活下丘脑和脑干摄食相关中枢内nesfatin-1神经元,其对摄食和胃排空障碍疾病调控具有潜在临床意义。硕士研究生:武庆杰(病理生理学)指导教师:徐珞教授关键词:腹部手术,Fos,下丘脑,Nesfatin一1,术后肠梗阻,脑干万方数据AbstractObjective:Toinvestigatetheeffectsofabdominalsurgery—inducedpostoperativeileusonnesfatin-1一immunoreactive(ir)neu4、ronsexpressionintheratbrain.Methods:RatswereanesthetizedwithsulfuricacidbumbarbitalandabdominalsurgeryWasperformed.Twohoursafterabdominalsurgery,ratsweretranscardiallyperfused.ThebraintissueswereprocessedfordoubleimmunohistochemicallabdingofFosandnesfatin.1.Results:ThereWa5、Sallobviousincreaseofc—Fosexpressioninneuronsofthesupraopficnucleus(SON)睁6.9,P<0.01),paraventricularnucleusoavrq3(mpPVN睁17.2;P6、raphepaUidus(rRPa)(卢2.57,P<0.05),nucleusofthesolitarytract(NTS)(卢10.46,P0.05).Thestatisticalanalysisshowedthatamongtheactivatedc—Fosneurons,99%intheSON,71%intheanteriorparvicell7、ularPVN,47%inthelateralmagnocellularPVN,41%inthemedialmagnocellularPVNand9%inthemedialparvicellularPVNcouldexpressnesfatin-1;inthebrainstem,afterabdominalsurgery,theactivatedc—Fosneurons91%intheLC,82%intherRPa,74%intheEWandVLM,14%intheNTSCouldexpressnesfatin-1.Conclusion:A8、bdominalsurgeryCallactivatethenesfatin-·1--irneuronsexpressedinsomefeeding—relatednucleii
2、副核(Ew)CFl0.74,P0.05)。但统计分析发现,腹部手术激活的c.Fos神经元中,在下丘脑SON内99%、apPVN内71%、lrIlPVN内47%、mmPVN内41%以及mpPVN内9%表达nesfatin-1;在脑干,腹部手术可分别激活LC内91%、rRPa内82%、EW和VLM内74%
3、、NTS14%表达c-Fos的nesfatin-t神经元。结论:腹部手术可激活下丘脑和脑干摄食相关中枢内nesfatin-1神经元,其对摄食和胃排空障碍疾病调控具有潜在临床意义。硕士研究生:武庆杰(病理生理学)指导教师:徐珞教授关键词:腹部手术,Fos,下丘脑,Nesfatin一1,术后肠梗阻,脑干万方数据AbstractObjective:Toinvestigatetheeffectsofabdominalsurgery—inducedpostoperativeileusonnesfatin-1一immunoreactive(ir)neu
4、ronsexpressionintheratbrain.Methods:RatswereanesthetizedwithsulfuricacidbumbarbitalandabdominalsurgeryWasperformed.Twohoursafterabdominalsurgery,ratsweretranscardiallyperfused.ThebraintissueswereprocessedfordoubleimmunohistochemicallabdingofFosandnesfatin.1.Results:ThereWa
5、Sallobviousincreaseofc—Fosexpressioninneuronsofthesupraopficnucleus(SON)睁6.9,P<0.01),paraventricularnucleusoavrq3(mpPVN睁17.2;P6、raphepaUidus(rRPa)(卢2.57,P<0.05),nucleusofthesolitarytract(NTS)(卢10.46,P0.05).Thestatisticalanalysisshowedthatamongtheactivatedc—Fosneurons,99%intheSON,71%intheanteriorparvicell7、ularPVN,47%inthelateralmagnocellularPVN,41%inthemedialmagnocellularPVNand9%inthemedialparvicellularPVNcouldexpressnesfatin-1;inthebrainstem,afterabdominalsurgery,theactivatedc—Fosneurons91%intheLC,82%intherRPa,74%intheEWandVLM,14%intheNTSCouldexpressnesfatin-1.Conclusion:A8、bdominalsurgeryCallactivatethenesfatin-·1--irneuronsexpressedinsomefeeding—relatednucleii
6、raphepaUidus(rRPa)(卢2.57,P<0.05),nucleusofthesolitarytract(NTS)(卢10.46,P0.05).Thestatisticalanalysisshowedthatamongtheactivatedc—Fosneurons,99%intheSON,71%intheanteriorparvicell
7、ularPVN,47%inthelateralmagnocellularPVN,41%inthemedialmagnocellularPVNand9%inthemedialparvicellularPVNcouldexpressnesfatin-1;inthebrainstem,afterabdominalsurgery,theactivatedc—Fosneurons91%intheLC,82%intherRPa,74%intheEWandVLM,14%intheNTSCouldexpressnesfatin-1.Conclusion:A
8、bdominalsurgeryCallactivatethenesfatin-·1--irneuronsexpressedinsomefeeding—relatednucleii
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