胃袖状切除术对PCOS肥胖大鼠下丘脑kisspeptin表达的影响

《胃袖状切除术对PCOS肥胖大鼠下丘脑kisspeptin表达的影响》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、福建医科大学硕士学位论文分类号：R588.6学校代码：10392学科专业代码：100201学号：2151003477硕士学位论文胃袖状切除术对PCOS肥胖大鼠下丘脑kisspeptin表达的影响TheEffectofSleeveGastrectomyonTheExpressionofKisspeptininHypothalamicofPCOSFatRats学位类型：医学硕士（学术型）所在学院：省立临床医学院申请人姓名：温玲英学科、专业：内科学(内分泌与代谢)导师：温俊平副教授研究起止日期：2016年3月至2018年3月答辩委员会主席：杨立勇教授答辩日期：2018年5月11日

2、二○一八年五月福建医科大学硕士学位论文目录英文缩略表„„„„„„„„„„„„„„„„„„„„„„„01中文摘要„„„„„„„„„„„„„„„„„„„„„„„„02英文摘要„„„„„„„„„„„„„„„„„„„„„„„„04前言„„„„„„„„„„„„„„„„„„„„„„„„„„06第一部分DHEA加高脂饮食SD大鼠的PCOS肥胖动物模型建立及其下丘脑kisspeptin表达的变化引言„„„„„„„„„„„„„„„„„„„„„„„„10材料与方法„„„„„„„„„„„„„„„„„„„„„„11实验结果„„„„„„„„„„„„„„„„„„„„„„„23讨论„„„„„„„„„„„

3、„„„„„„„„„„„„„32第二部分胃袖状切除术对PCOS肥胖大鼠下丘脑kisspeptin表达的影响引言„„„„„„„„„„„„„„„„„„„„„„„„36材料与方法„„„„„„„„„„„„„„„„„„„„„„37实验结果„„„„„„„„„„„„„„„„„„„„„„„41讨论„„„„„„„„„„„„„„„„„„„„„„„„53研究结论„„„„„„„„„„„„„„„„„„„„„„„„56参考文献„„„„„„„„„„„„„„„„„„„„„„„„57课题综述代谢手术对肥胖患者性功能和性激素水平的影响„„„64致谢„„„„„„„„„„„„„„„„„„„„„„„„„„72福建医科

4、大学硕士学位论文英文缩略表英文缩写英文全称中文名称DHEADehydroepiandrosterone脱氢表雄酮PCOSPolycysticovarysyndrome多囊卵巢综合征BMIBodymassindex体重指数ELISAEnzyme-linkedimmunosorbentassay酶联免疫方法PBSPhosphastebuffersaline磷酸盐缓冲液GnRHGonadotropin-releasinghormone促性腺激素释放激素LHLuteinizinghormone黄体生成素FSHFolliclestimulatinghormone卵泡刺激素E2Estr

5、adiol雌二醇PProgesterone孕酮TTestosterone睾酮GPR54G-protein-coupledreceptor54G蛋白偶联受体54ARCArcuatenucleus弓状核AVPVAnteroventralperiventricularnucleus前腹室周核LSGLaparoscopicsleevegastrectom腹腔镜胃袖状切除术LAGBLaparoscopicadjustablegastricbanding腹腔镜可调节胃束带术LRYGBLaparoscopicRoux-en-Ygastricbypass腹腔镜Roux-en-Y胃旁路术NK

6、BNeurokininB神经激肽BNPYNeuropeptideY神经肽YDHTDihydrotestosterone双氢睾酮FISHFluorescenceinsituhybridization荧光原位杂交IHCImmunohistochemistry免疫组织化学SHBGSexhormonebindingglobulin性激素结合球蛋白TTTotaltestosterone总睾酮FTFreetestosterone游离睾酮WHOWorldhealthorganization世界卫生组织AdenosineMonophosphateActivatedAMPK腺苷酸活化蛋白激酶

7、ProteinKinaseIPGTTIntraperitonealglucosetolerancetest腹腔葡萄糖耐量试验IPITTIntraperitonealinsulintolerancetest腹腔胰岛素耐量试验1福建医科大学硕士学位论文胃袖状切除术对PCOS肥胖大鼠下丘脑kisspeptin表达的影响中文摘要目的：本研究通过脱氢表雄酮（DHEA）构建多囊卵巢综合征（PCOS）SD大鼠模型，并予高脂喂养，探讨PCOS肥胖大鼠下丘脑kisspeptin表达的变化。并观察胃袖状切除术对DHEA加高脂饮食诱导的