心肌营养素1在缺氧后适应中对心肌保护作用的探讨-(5850)

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1、硕士学位论文表达下调。加入Akt阻滞剂(A6730)后，缺氧后适应+CTl+Akt抑制剂组较缺氧后适应+CTl组凋亡率增加，存活率降低，Akt磷酸化蛋白水平下降，BadmRNA表达升高，缺氧后适应+CTl+二甲基亚砜组较缺氧后适应+CTI+Akt抑制剂组凋亡率降低，存活率增加，Akt磷酸化蛋白水平明显升高，BadmRNA表达下调，基本与缺氧后适应+CTl组持平。结论心肌营养素1参与激活缺氧后适应Akt信号通路，协同缺氧后适应减轻缺氧复氧再灌注对心肌细胞的损伤，对心肌细胞起保护作用。关键词：心肌细胞缺氧后适应心肌营养素lAkt信号通路V硕士学位论

2、文ExplorecardiotrophinIinischemicpostconOitionin20nmyocardialprotectivell●l■J■■●l·一■effectsName：ZhaoXinSupervisor：Prof．LiuYingfengABSTRACTWiththecontinuousimprovementofpeople’Slivingstandards，unhealthylifestylehasincreasedgradually，andthespectrumofdiseasewhichthreatstohumanhe

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4、ore．totreatacutemyocardialinfarctionandtorescueendangeredthelivesofpatientsareparticularlyimportant，andalsoarearduoustask．Thetreatmentofacutemyocardialinfarctionisnothingmorethanthefollowingthreemethods：theclassicdrugtreatment，thepercutaneouscoronaryinterventiontreatment，and

5、thetreatmentofcoronaryarterybypassgrafting．Afterlongtermclinicalobservation，itisfoundthatwhichevermethodyouchoose，myocardialinfarctsizeofthepatientswithacutemyocardialinfarctionwillexpandfurtherwhenthelesionbloodvesselsareopenedandtheremotebloodsupplyarerecovered．Thediastoli

6、candsystolicfunctionshaveobstaclesorthepatienthasseverearrhythmias，anditevenledtodeath；thisismyocardialischemia-reperfusioninjuryphenomenon．Sotoeasemyocardialreperfusioninjuryhasbecomeanurgentprobleminthecourseoftreatmentofacutemyocardialinfarction．In1986，Murryet．alsuggested

7、thatitmaypreventormitigatethesubsequentprolongedischernia-inducedmyocardialinjuryaftermyocardiumexperiencedseveralABSTRACTbrief,repeatedmyocardialischemiaandreperfusion；thisisischemicpreconditioning(Ischemicpreconditioning，IPC)．Subsequentclinicalstudiesconfirmitsmyocardialpr

8、otectiveeffect，buttheclinicalapplicationislimitedbecauseofoperationalproble