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ID:33218303
大小:8.05 MB
页数:40页
时间:2019-02-22
《米诺环素对慢性脑低灌注大鼠空间学习记忆能力及海马bace-1和aβ表达的影响》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、遵义医学院硕士学位论文米诺环素对慢性脑低灌注大鼠空间学习记忆能力及海马BACE--1和Aβ表达的影响姓名:李国艳申请学位级别:硕士专业:神经病学指导教师:余昌胤20120531遵义医学院硕士学位论文米诺环素对慢性脑低灌注大鼠学习记忆及BACE矛11A13的影响米诺环素对慢性脑低灌注大鼠空间学习记忆功能力及海马BACE-1和A13表达的影响、摘要目的:观察米诺环素对慢性脑低灌注大鼠空间学习记忆能力及海马BACE.1和A13表达的影响,为慢性脑低灌注认知功能障碍的治疗提供依据。方法:72只SD大鼠随机分为9组:假手术组(
2、分为造模后1月、2月、3月),慢性脑低灌注组(模型组,分为造模后1月、2月、3月),米诺环素治疗组(治疗组,分为造模后1月、2月、3月),每组8只。结扎双侧颈总动脉建立大鼠慢性脑低灌注模型,假手术组除不结扎双侧颈总动脉外,其余与慢性脑低灌注组手术操作相同,米诺环素治疗组在慢性脑低灌注模型的基础上连续给予50mg/kg/d的米诺环素灌胃。假手术组和慢性脑低灌注组每天给予等量生理盐水处理。观察时间点分别为造模后1月、2月和3月。采用Morris水迷宫对大鼠进行定位航行潜伏期和空间探索时间检测后,断头取脑,采用免疫组织化学
3、法检测海马区脑组织BACE.1和A13。结果:(1)在1月、2月或3月时间点,模型组定位航行潜伏期较假手术组明显延长(PD.05)。(2)模型组BACE.1和A13的表达较假手术组明显增加(P4、无显著性(P>D.05)。(3)组内比较,假手术组和治疗组各观察时间点上述各观察指标差异无显著性(尸>D.05)。随着时间的推移,模型组潜伏期逐渐延长,空间探索时间逐渐减少,BACE.1和A13的表达显著增加(尸5、ctsofMinocyclineonSpatialLearningandMemoryAbilityandExpressionofBACE-1andABinHippocampausinaRatwithChronicCerebralHypoperfusionAbstractobjective::Toobservetheminocyclineinfluencesonlearningandmemoryabilityinratswithchroniccerebralhypoperfusion,andtheexpressiono6、fBACE一1,Apinbrain.Thestudyprovidedanevidenceforclinictreatingcognitiveimpedimentafterchroniccerebralhypoperfusion.Methods:Total72Sprague-Dawlayrats,randomlydividedinto3groups:shamgroup(n=24),CCHgroup(n-24),minocyclinegroup(n=24),theneachgroupwasrandomlydividedi7、nto3groupsat1吼,2吼,3砒month,n=8.CCHgroupwerefollowedocclusionofbilateralcommoncarotidarteries(2-vo),shamgroupwashandledasCCHgroupexceptnotligatingbilateralcommoncarotidarteries.Minocyclinegroupwereinjectedminocyciine(50mg/kg/d)onthebaseofCCHgroup,shamgroupandCCHg8、roupwereinjectedisodosesaline.Therewere3observationaltimepointsineverygroup:1吼,2吼,38‘monthafteroperationwithrats.Eachgroupratswereexecutedthelatencyofplacenavigationandspati
4、无显著性(P>D.05)。(3)组内比较,假手术组和治疗组各观察时间点上述各观察指标差异无显著性(尸>D.05)。随着时间的推移,模型组潜伏期逐渐延长,空间探索时间逐渐减少,BACE.1和A13的表达显著增加(尸5、ctsofMinocyclineonSpatialLearningandMemoryAbilityandExpressionofBACE-1andABinHippocampausinaRatwithChronicCerebralHypoperfusionAbstractobjective::Toobservetheminocyclineinfluencesonlearningandmemoryabilityinratswithchroniccerebralhypoperfusion,andtheexpressiono6、fBACE一1,Apinbrain.Thestudyprovidedanevidenceforclinictreatingcognitiveimpedimentafterchroniccerebralhypoperfusion.Methods:Total72Sprague-Dawlayrats,randomlydividedinto3groups:shamgroup(n=24),CCHgroup(n-24),minocyclinegroup(n=24),theneachgroupwasrandomlydividedi7、nto3groupsat1吼,2吼,3砒month,n=8.CCHgroupwerefollowedocclusionofbilateralcommoncarotidarteries(2-vo),shamgroupwashandledasCCHgroupexceptnotligatingbilateralcommoncarotidarteries.Minocyclinegroupwereinjectedminocyciine(50mg/kg/d)onthebaseofCCHgroup,shamgroupandCCHg8、roupwereinjectedisodosesaline.Therewere3observationaltimepointsineverygroup:1吼,2吼,38‘monthafteroperationwithrats.Eachgroupratswereexecutedthelatencyofplacenavigationandspati
5、ctsofMinocyclineonSpatialLearningandMemoryAbilityandExpressionofBACE-1andABinHippocampausinaRatwithChronicCerebralHypoperfusionAbstractobjective::Toobservetheminocyclineinfluencesonlearningandmemoryabilityinratswithchroniccerebralhypoperfusion,andtheexpressiono
6、fBACE一1,Apinbrain.Thestudyprovidedanevidenceforclinictreatingcognitiveimpedimentafterchroniccerebralhypoperfusion.Methods:Total72Sprague-Dawlayrats,randomlydividedinto3groups:shamgroup(n=24),CCHgroup(n-24),minocyclinegroup(n=24),theneachgroupwasrandomlydividedi
7、nto3groupsat1吼,2吼,3砒month,n=8.CCHgroupwerefollowedocclusionofbilateralcommoncarotidarteries(2-vo),shamgroupwashandledasCCHgroupexceptnotligatingbilateralcommoncarotidarteries.Minocyclinegroupwereinjectedminocyciine(50mg/kg/d)onthebaseofCCHgroup,shamgroupandCCHg
8、roupwereinjectedisodosesaline.Therewere3observationaltimepointsineverygroup:1吼,2吼,38‘monthafteroperationwithrats.Eachgroupratswereexecutedthelatencyofplacenavigationandspati
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