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ID:32255720
大小:3.69 MB
页数:45页
时间:2019-02-02
《川芎嗪靶向内皮细胞抗动脉粥样硬化作用的研究》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、AntiatherosclerosisinducedbyligustrazinetargetingendotheliumSPeeiality:CardiovaseularDisease,IniernalMedieineofIntegratedTCMandWestemMedieineAuthor:Guofeng认/angTutor:ProfessorChuanllua、认ngAbstraetObjeetive:1.ToexaminetheantiatheroselerotieeffieaeyindueedbyLIGanditsunderiyin
2、gmech丽sms.2.TowidenitseliniealusageseoPe,toProvidesensitivemarkersforeliniealdiagnoseintheearliertimeofatheroselerosis.Methods:1.IninvivoeXPeriments,rabbitsfed勿highcholesteroldicthavebeenusedtoevaluatetheanti毗eroselerotieemeaeyofLlo(75,一somg.kg一,)ineludingpl叫ueSurfaceareain
3、anrta,I/M,foameellamotmts,seru们nliPidlevelofTC,TG,LDL一CandHDL一C.2.F叭herinvestigationhadbeene翻edoutininvitroexPerimentsinducedbyox一LDLinHCAECthroughexami正ngtheeffeetsofLIGonthegeneandProteineXPressionofMCP一l,ICAM一l,COX一2andtheireorn们nonrelatedsignalPathwayssuehasNF一妞.3.AProt
4、eomieanalysisofLIGagainstox一LDL一indueedHCAECwasPerformed.ThediffereniiallyexPressedProteinsindueedbyLIGwereideniifiedbyusingLC一ESI一MS[MS,theSWISS一PROTdatabaseandKEGGsignalsforeeast.FurtherfunctionvalidationofthesePathwaysandtargetsinendothelialeellswereeariedout.Results:1.L
5、IGeouldredueethepl明uesurfaceareainaortaat出edoseof75andzsomg.kg一1.FMand扔ameellamountswerealsodeereased.Inaddition,serumlipidlevelofTC、TGandLDLhadbeendePressed,howeverserumlevelofHDLhadnoehanges.2.LIGmarkedlydeereasedthegeneandProteinexPressionofMCP一1,ICAM一1andCOX一2attheconce
6、ntrationofl,10and100林M.ThetransloeationofNF一忍tonuclearhadbeenrestrained.3.TwelveofaPProximately400detectedProteinswereeitherinereasedordeereasedinabundaneeasaresultoftreatmeniwithLIG.Alnongthem,9sPotsweremorethanZ一folduP一regulatedand3weremorethanZ一folddown一regulatedbyLIGeom
7、Paredwithox一LDL一treatedsamPles,identifiedbyeomP而ngmassesoftheirtryPtiePePtideswiththoseofknownProteins,usingLC一ESI·MS从5andtheSWISS一PROTdatabase.TheirfunetionshavebeenanotatedinEXPasydatabasesincludingliPidandenergymetabolism,ehaperone,reeePtortyrosinekinases,eytoskeletonreg
8、ulationandubiquitin一Proteasomesystem(UPS).Conclusion:1.Antlatheroselerotieeffeetsi
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