脱氢水飞蓟素磷脂复合物脂质纳米粒的分析

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1、江苏大学硕+学位论文ABSTRACTMilkthistle(Silybummarianum(L．)Gaeritn．)isoneofthefewherbaldrugswhoseexcellentpharmacologicalprofilereadilylendsitselftoproofofclinicalefficacy．Silymarin，astheseedsextractofthemilkthistle，whosemainactivecompoundsaretheflavonoidssilybin，silydiani

2、nandsilychristineisahepatoprotectiVeagentthatiswidelyusedtotreatvariouskindsofliverdisorders．However,silymarinisslightlysolubleinwater,withlowlipidsolubilityfollowedbylowbioavailabilityafteroraladministration，whichconsiderablycompromisethetherapeuticefficacyofsil

3、ymarin．Dehydrosilymarinweprepared，anoxidizedformofsilymarin，exhibitedgreaterpharmacologicalactivityincomparisonwithsilymarin．Nevertheless，thewater-solubilityofdehydrosilymarinWasalsoverypoor,whichdiscountedthefavorableeffectivenessofdehydrosilymarin．Toincreasethe

4、solubilityofdehydrosilymarineffectively,improveitsoralbioavailability,andpreparenewdosageformswhicharesuitableforindustrialproduction，lipidnanoparticlesofdehydrosilymarin—phospholipidcomplexweredesignedanddevelopedinourpaper．Priortothepreparationoflipidnanopartic

5、les，weproduceddehydrosilymarinphospholipidcomplexinitiallywhichwasconvenientfortheformationofproliposomesandself-microemulsifyingdrugdeliverysystem(SEDDS)．Differentmethodswereemployedtoevaluatelipidnanoparticlescorrespondingly．Thewholepaperisorganizedintofourpart

6、s．1．Review．Thisreviewincludessixparts：Chapteroneandtworeviewthecurrentstatusandprogressofstudiesinextractsfrom(Dehydro)Silybummarianum．Theresearchdevelopmentofphospholipidcomplexisbrieflydescribedinchapterthree．Lipidnanoparticlesaresummarizedinchapterfour,suchasl

7、iposomes，SEDDSandsolidlipidnanoparticles．ChapterfivemakesanintroductiontotheresearchsituationoflipidnanoparticlesofextractsfromSilybummarianum．Chaptersixpresentsthetheoreticalpurposeandbasis．脱氢水飞蓟素磷脂复合物脂质纳米粒的研究2．Preparationandcharacterizationofdehydrosilymarin-ph

8、ospholipidcomplex．Dehydrosilymarinwaspreparedfromtheairoxidationofsilymarinwiththepresenceofpyridine．Theidealpreparationprocesswereoptimizedwiththeuseoftheyiel