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1、慢性肝病与血清PreSl-Ag、HBVDNA和HBVM相关性分析姚红玉沈蓉陈陶阳樊健[摘要]目的探讨血清PreSl-Ag、HBVDNA以及HBVM在慢性肝病中的临床价值。方法对338例慢性乙型肝炎、80例肝硬化和61例肝癌患者,检测其PreSl-Ag、HBVDNA和HBVM的阳性状态及其差异,采用KaPPa一致性检验HBVPreSl-Ag与HBVDNA的阳性一致性。结果肝癌患者与PreSl-Ag(39.34%)和HBVDNA(34.43%)的阳性水平显著低于肝硬化(48.75%,46.25%),更低于慢性乙型肝炎患者(63.02%,74.26%)。三组慢性肝病患者均以三种HBV模式为主
2、,其中,HBsAg、抗HBe、抗HBc阳性模式较多发生肝硬化和肝癌。PreSl-Ag与HBVDNA的阳性水平有良好的一致性。结论慢性肝病与PreSl-Ag、HBVDNA和HBVM具有相关性,HBVM不同模式存在状态与疾病转归有明显关系,PreSl-Ag对判断HBV在感染与复制中異有重要临床意义。[关键词]慢性肝病PreSl-AgHBVDNAHBVM相关性AnAnalysisoftheCorrelationbetweenChronicLiverDiseaseandSerumPreSl-Ag,HBVDNAandHBVMYaoHongyu,ShenRong,ChenTaoyang,FanJi
3、anAbstract:ObjectiveToinvestigatetheclinicalvalueofserumPreSl-Ag,HBVDNAandHBVMinchronicliverdiseases.MethodsPositivestatusofPreSl-Ag,HBVDNAandHBVMof338casesofchronichepatitisB,80patientswithlivercirrhosisand61patientswithlivercancerweretestedtoknowtheirdifferences.ThepositiveconsistencyofHBVPreS
4、l-AgandHBVDNAweretestedbyKaPPaconsistencytest.ResultsThepositivelevelofhepatocellularcarcinomapatients’PreSl-Ag(39.34%)andHBVDNA(34.43%)waslowerthanpatientwithcirrhosis(48.75%,46.25%),andevenlowerthanpatientswithchronichepatitisB(63.02%,74.26%).Threegroupsofpatientswithchronicliverdiseasea
5、llmainlycontainsthethreekindsofHBVmode,ofwhichtheHBsAg,antiHBe,antiHBcpositivepatternwereoftenfoundinlivercirrhosisandhepatocellularcarcinoma.ThepositivelevelofPreSl-AgandHBVDNAhavegoodconsistency.ConclusionChronicliverdiseasesisassociatedwithPreSl-Ag,HBVDNAandHBVM.DifferentmodeofHBVManditsexist
6、ingstatehaveobviousrelationshipwiththeprognosisofthedisease.PreSl-AgdiagnosishasimportantclinicalsignificanceintheinfectionandreplicationofHVB.Keywords:chronicliverdisease;PreSl-Ag;HBVDNA;HBVM;correlation研究表明,HBV感染后有表现于隐性感染、急性肝炎、慢性肝炎,甚至暴发性肝炎、肝硬化和肝癌【1】,而实验室检査主要依据PreSI、HBVDNA、HBVM及肝功能等项0的检测【2-6】。H
7、BVDNA是临床判断HBV复制和传染性的可靠指标[21传统的血清HBV标志物(HBVM)反映HBV在体内存在的状况【3】。HBV前S1抗原(PreSl-Ag)暴露于颗粒表面,是HBV与肝细胞膜上特异性受体相结合的主要蛋白成分,在HBV感染肝细胞和机体免疫应答中起重要作用,近年来,通过HBVPreSl-Ag在乙型肝炎发病机制、HBV感染与复制等方面的深入研究【4,5】,反映乙型肝炎病毒在体内感染及复制状况的具冇重要价值。为此,我们对慢性肝病与血清