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1、氟比洛芬酯复合曲马多对腹部手术患者持续静脉镇痛的临床研宄何江1张欣宁2许春雷1诸月妮2（1清远市人民医院麻醉科广东清远511500）（2清远市人民医院妇科广东清远511500）【摘要】目的观察氟比洛芬酯复合曲马多用于腹部手术患者持续静脉镇痛的有效性及安全性。方法选择ASA分级I〜II级、择期行腹部手术的患者80例，随机分为氟比洛芬酯（F组）和曲马多组（T组），每组40例。F组首量为氟比洛芬酯50mg,镇痛泵
2、Aj加入氟比洛芬酯200mg、曲马多400mg和托烷司烷5mg并用生理盐水稀释至100mloT组首量为曲马多100mg,镇痛泵内
3、加入曲马多800mg和托烷司琼5mg并用生理盐水稀释至100ml。两组均设定相同的PCA参数（2ml/h,按压0.5ml/次，锁定时间15min）。于术后1,3,6,12,24和48h观察并记录患者各时点的VAS评分、统计术后48h内PCIA按压次数及不良反应。结果F组与T组术后VAS评分及术后48h按压次数差异无统计学意义，但不良反应存在差异,F组不良反应发生率明显低于T组。结论腹部手术患者持续静脉镇痛应用氟比洛芬酯复合曲马多静脉持续镇痛具有安全、效果确切及不良反应少的优点。【关键词】氟比洛芬酯曲马多静脉镇痛腹部手术【屮图分类号】R
4、614【文献标识码】A【文章编号】2095-1752（2014）06-0219-02ClinicalResearchofFlurbiprofenAxetilCombinedTramadolforPatient-controlledIntravenousAnalgesiaAfterAbdominalSurgeries【Abstract】ObjectiveToobservetheefficacyandsafetyofflurbiprofenaxetilcombinedtramadol,usedforpostoperativepatient
5、-controlledintravenousanalgesiainpatientsundergoingabdominalsurgeries.Methods:EightyI〜IIlevelofASApatientsundergoingabdominalsurgerieswereenrolledinthisstudy.Patientswererandomlydividedintoflurbiprofengroup(groupF)andtramadolgroup(groupT),40casesineachgroup.Thepatientsi
6、nGroupFreceivedflurbiprofenaxetil50mgasinitialdose,theanalgesiapumpaddedwithflurbiprofenaxetil200mg,tramadol400mgandthromboxane5mganddilutedwithsalineto100ml.TheinitialdoseingroupTwastramadollOOmg,analgesiapumpaddedwithtramadol800mgand5mgtropisetronanddilutedwithsalinet
7、o100ml.ThetwogroupsweresetwiththesamePCAparameter(2ml/h,per-press0.5ml,lockouttimeofl5min).Afterpostoperationoflh,3h,6h,12h,24hand48h,observedthepatientsandrecordedtheVASscores,andstatisticsofpressingtimesandadversereactionafter48hPCIA.TheresultsofpostoperativeVASscorea
8、ndpostoperative48hpresstimeshavenosignificantdifferenceingroupFandgroupT,buttherearedifferencesinadversereactionsoccurred.TheadversereactionrateingroupFwasdearlylowerthanthatofgroupT.ConclusionTheusageofcombinationofFlurbiprofenaxetilwithTramadolusedinpatientsundergoing
9、abdominalsurgeriesinPCIA,canreduceadversereactions,andgetasatisfactoryanalgesiceffect.Itisasafe,effective,andc
