氟比洛芬酯用于静脉镇痛的临床观察

《氟比洛芬酯用于静脉镇痛的临床观察》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、氟比洛芬酯用于静脉镇痛的临床观察作者：郑恒兴，张康秦，乔英，王宵鹏，梁斌单位：721008陕西宝鸡市中心医院麻醉手术科科研项H宝鸡市卫牛局科研资助项廿【摘要】目的：观察氟比洛芬酯术后静脉镇痛的临床效果，最佳方案及不良反应。方法：选择期分别行颈胸部、脊柱、上腹部、下腹部和四肢等四个部位手术患者400例实施术后静脉镇痛，每部位患者100例。每部位手术患者随机分为四组，镇痛泵配制方案I组：芬太尼20μg/kg;II组：芬太尼10μg/kg+氟比洛芬酯0.8〜lmg/kg;III组：芬太尼10&

2、mu;g/kg+氟比洛芬酯1.6〜2mg/kg;IV组：芬太尼10μg/kg+氟比洛芬酯0.8〜lmg/kg,并于麻醉前静注氛比洛芬酯0.8-Img/kgo各组镇痛泵均以0.9%牛理盐水稀释到lOOmlo镇痛期间观察患者48小时内镇痛效果(VAS法)、血流动力学变化及其恶心、呕吐的发牛率。结果：四个手术部位患者各组在术后镇痛期间血流动力学变化无明显差异;各手术部位患者的术后镇痛效果，第III.IV组均明显优于第I、II组(P<0・01),且下腹部和四肢部位手术患者的术后镇痛效果，第IV组

3、明显优于第III组(P<0.05);各手术部位患者恶心、呕吐发生率第II、III、IV组均明显低于第I组(P<0.05)。结论：①氟比洛芬酯川于静脉术后镇痛可明显增加镇痛效果，降低芬太尼用量，减少患者的恶心、呕吐发生率;②氟比洛芬酯剂量增加可明显增加各部位于•术患者的术后镇痛效果;③氟比洛芬酯超前镇痛可以明显增强局部麻醉(椎管内麻醉、神经阻滞等)术后镇痛效果。【关键词】术后镇痛静脉氟比洛芬酯AbstractObjective:Tostudytheeffects,optimalschedu

4、leandadverseeffectsofflurbiprofenaxetilforpostoperativeintravenousanalgesia.Methods:FourhundredpatientsASAI~IIweredividedintooperationonneckandthoraxregion(NT),columnavertobralisregion(CV),upperabdominalregion(UA),and,lowerabdomenandlimbsregion(LL).Eac

5、hregionwithonehundredpatients.Allpatientswereadministratedwithpostoperativeintravenousanalgesia.Patientsofeachoperatedregionweredividedrandomlyintofourgroups.ThedrugsofanalgesiapumpwereformulatedbygroupIwithfentanyl20μg/kg,groupIIwithfentanyll()μ

6、g/kg+flurbiprofenaxetil0.8^1mg/kg,groupIIIwithfentanyll()μg/kg+flurbiprofenaxetil1.6〜2mg/kg,groupIVwithfentanyllOμg/kg+flurbiprofenaxetil0.8~lmg/kg・AndpatientsingroupIVwerealsoenforcedwithinjectionofflurbiprofenaxetil0.8〜1mg/kgbeforeanesthesia.Th

7、eformulateddrugsweredilutedto100mlby0.9%physiologicalsaline.Toobservedanalgesiaeffectiveness(byVASmethod),hemodynamics,andincidenceofnauseaandvoinitingofeachpatientsduring48hoursafterpostoperativeintravenousanalgesia.Results:Thehemodynamicsofeachpatien

8、twerenotsignificantlyvariationduring48hoursanalgesiaperiod.Theanalgesiaeffectsofgroup111andIVwereobviouslybetterthanthatofgroupIandIIinalloperationregionpatients(P<0.01),andtheeffectsofgroupIVwerealsoobviouslybetterthanthatofgroupIII