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of hepatitis c surveillance丙型肝炎监测目标课件

of hepatitis c surveillance丙型肝炎监测目标课件

ID：18881008

大小：1.88 MB

页数：55页

时间：2018-09-20

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1、A“Infectious”“Serum”ViralhepatitisEntericallytransmittedParenterallytransmittedotherE“NANB”BDCVIRALHEPATITISHISTORICALPERSPECTIVEREPORTEDCASESOFSELECTEDNOTIFIABLEDISEASESPREVENTABLEBYVACCINATION,UNITEDSTATES,2001HepatitisAHepatitisBPertussisMeningococcaldiseaseH.influenzae

2、,invasiveMumpsMeaslesSource:NNDSS,CDC10,6097,8437,5802,3331,597266116HEPATITISAVIRUSHEPATITISAVIRUSRNAPicornavirusSingleserotypeworldwideAcutediseaseandasymptomaticinfectionNochronicinfectionProtectiveantibodiesdevelopinresponsetoinfection-conferslifelongimmunityHEPATITISA

3、-CLINICALFEATURESJaundiceby<6yrs<10% agegroup:6-14yrs40%-50% >14yrs70%-80%Rarecomplications:Fulminanthepatitis Cholestatichepatitis RelapsinghepatitisIncubationperiod:Average30days Range15-50daysChronicsequelae:None012345678910111213WeekResponseClinicalillnessALTIgMIgGHAVi

4、nstoolInfectionViremiaEVENTSINHEPATITISAVIRUSINFECTIONCONCENTRATIONOFHEPATITISAVIRUSINVARIOUSBODYFLUIDSSource:ViralHepatitisandLiverDisease1984;9-22JInfectDis1989;160:887-890FecesSerumSalivaUrine1001021041061081010BodyFluidsInfectiousDosespermLEndemicityDiseaseRatePeakAgeo

5、fInfectionTransmissionPatternsEarlychildhoodLatechildhood/youngadultsYoungadultsHighModerateLowVerylowLowtohighHighLowVerylowAdultsPersontoperson;outbreaksuncommonPersontoperson;foodandwaterborneoutbreaksPersontoperson;foodandwaterborneoutbreaksTravelers;outbreaksuncommonG

6、LOBALPATTERNSOFHEPATITISAVIRUSTRANSMISSIONGEOGRAPHICDISTRIBUTIONOF HEPATITISAVIRUSINFECTIONMostdiseaseoccursinthecontextofcommunity-wideoutbreaksInfectiontransmittedfrompersontopersoninhouseholdsandextendedfamilysettings-facilitatedbyasymptomaticinfectionamongchildrenSomeg

7、roupsatincreasedriskspecificfactorvariesdonotaccountformajorityofcasesNoriskfactoridentifiedfor40%-50%ofcasesHEPATITISA,UNITEDSTATESACUTEHEPATITISACASE DEFINITIONFORSURVEILLANCEClinicalcriteriaAnacuteillnesswith:discreteonsetofsymptoms(e.g.fatigue,abdominalpain,lossofappet

8、ite,intermittentnausea,vomiting),andjaundiceorelevatedserumaminotransferaselevelsLaborato

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