Hepatitis B Post Vaccination Surveillance：乙型肝炎疫苗接种后的监测

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1、WORLDHEPATITISDAY2013Johannesburg,Gauteng29thJuly,2013HEPATITISB:Post-VaccinationSurveillanceHeadSouthAfricanVaccinationandImmunisationCentreCo-DirectorWHORotavirusRegionalReferenceLaboratoryforAfrica&MRC/ULDiarrhoealPathogensResearchUnitProfessorandAcademicChairDepartmentofViro

2、logy,UniversityofLimpopo(MedunsaCampus)&NationalHealthLaboratoryService,PRETORIA,SouthAfricaEdinaAmponsah-DacostaOnbehalfofIntroductionofhepatitisBvaccineintoNIPsMethodstoevaluateimpactofhepatitisBvaccinationShort-termvs.long-termmeasureofimpactofvaccinationExamplesofrepresentat

3、ivenationwidesero-surveysofimpactofhepatitisBvaccinationConcludingRemarksHepatitisBvaccineisthefirstvaccineagainstcancerAvailablesincetheearly80’sPrevents>0.5milliondeaths/yearfromacuteandchronichepatitisBvirus(HBV)infectionRecommendationbyWHO(1994)HepBvaccineshouldbeintroducedi

4、ntoNIPs:CountrieswithHBsAgprevalence8%by1995Globalintroductionby1997SouthAfricawasamongthefirst10countriestointroducehepatitisBvaccineontheAfricancontinent(April,1995)IntroductionofhepatitisBvaccineintoNIPsHugediscrepanciesbetweenimmunizationcoverageestimatesreportedbyNDoH/EPIu

5、nitandthosepublishedbyWHO/UNICEFRoutinelycollectedimmunizationcoveragedataisstillnotcompletelyreliableandcannotasyetbeusedtoaccuratelymonitorcoverageorinfervaccineimpactWHO/UNICEFEstimatesHepatitisBpreventionprogrammeandmonitoringvaccineimpactPOST-VACCINATIONSURVEILLANCEDefineep

6、idemiologyofdiseaseAssessandquantifydiseaseburdenDevelopcomprehensivepreventionstrategyIdentifyresources&implementvaccineEnsuresustainabilityEvaluateprogrammeeffectivenessMonitorImpactHepatitisBisgrosslyunder-diagnosedandunder-reporteddifficulttoquantifyandassessburdenofinfectio

7、ndifficulttoquantifyandassessburdenofdiseaseToassessimpactofvaccinationmeasuretheburdenofdiseaseorburdenofinfection?Sero-survey++++++I++++++PrevalenceofinfectionAcuteDiseaseSurveillance++++++IorC*++++IncidencenewinfectionRiskfactorinformationMorbidity&Mortality+++++IorC++++Incid

8、encechronicsequeleaFeasibilityExpenseFrequencyo