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1、EBMExperimentalBiologyandMedicineEffectofPre-LoadingOralGlucosamineHCl/ChondroitinSulfate/ManganeseAscorbateCombinationonExperimentalArthritisinRatsJoelBeren,SusanL.Hill,MarieDiener-WestandNoelR.RoseExperimentalBiologyandMedicine2001,226:144-151.Updatedinformationandservicescanbef
2、oundat:http://ebm.rsmjournals.com/content/226/2/144©2008SocietyforExperimentalBiologyandMedicineDownloadedfromhttp://ebm.rsmjournals.com/byguestonOctober12,2011EffectofPre-LoadingOralGlucosamineHCl/ChondroitinSulfate/ManganeseAscorbateCombinationonExperimentalArthritisinRats,1,1,,
3、2JOELBEREN,*SUSANL.HILL,†MARIEDIENER-WEST,†ANDNOELR.ROSE*†*DepartmentofPathology,†TheW.HarryFeinstoneDepartmentofMolecularMicrobiologyandImmunology,and†DepartmentofBiostatistics,TheJohnsHopkinsMedicalInstitutions,Baltimore,Maryland21205Thetherapeuticeffectofanutritionalsupplementc
4、onsistingofheumatoidarthritis(RA)isasignificanthealthprob-acombinationofglucosaminehydrochloride(FCHG49),puri-lemintermsofnumbersofsufferers(U.S.incidencefiedsodiumchondroitinsulfate(TRH122),andmanganeseR323.7/100,000)andindegreeofassociateddisabilityascorbate(GCM)wasinvestigatedi
5、ntheratmodelofcollagen-inducedautoimmunearthritis(CIA).TheGCMcompoundwasaswell(1).Thediseaseischaracterizedbyachronicandmixedwithapalatablenutritionalpaste(Nutri-cal[NC]).Oraldestructiveinflammatoryreaction,possiblyautoimmuneinadministrationoftheNC/GCMcompoundwasinitiatedin26etio
6、logy,attackingthesynovialmembranesofjointsandrats10daysbeforeimmunizationandcontinueduntilthedayofmanyothertissuesofthebody.Muchhasbeenlearnedinsacrifice.Onegroupof12controlratswasgivennooralagents;asecondgroupof12controlratsreceivedNConly.Evaluationsrecentyearsaboutthepathogenesi
7、sofRA.Geneticpredis-includedarthritisindex(AI)scoringbythreeindependentevalu-positionandexogenousarthritogensarebelievedtocontrib-ators,histologicindex(HI)scoringoflesions,T-cellprolifera-utetoaT-cell-mediatedautoimmunereactiontooneortion,andserologicalstudiesforantibodyclassesand
8、sub-moreconstituentsofthejoint.So
