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1、参附注射液对慢性心力衰竭心功能及血浆NT-proBNP的影响旦中医多症2011年8月第20卷第8期JETCM.Aug.2011,Vo1.20,No.8参附注射液对慢性心力衰竭心功能及血浆NT—proBNP的影响术吴华芹胡元会△周育平安成褚瑜光冯玲中国中医科学院广安f-j医院(北京100053)中图分类号:R541.6l文献标志码:B文章编号:1004—745X(2011)08—1207—02【摘要】目的观察参附注射液对慢性心力衰竭(CHF)患者心功能及血浆N一末端原脑利钠肽(N—terminal—proB—TtypeNatriureticP
2、eptide,NT-proBNP)水平的影响.方法将63例CHF患者随机分为两组.对照组采用西医常规治疗,治疗组在西医常规治疗的基础上加用参附注射液静滴.治疗7d后比较两组的心功能指标及血浆NT-proBNP水平的变化.结果两组治疗后左室舒张末内径,左室射血分数,心输出量,左室短轴缩短率均较治疗前有改善,治疗组改善的程度优于对照组;两组治疗后血浆NT—proBNP水平均较疗前有下降.治疗组下降更明显.结论参附注射液可明显改善慢性心力衰竭患者心脏舒缩功能,显着降低其血浆NT—proBNP水平.【关健词】参附注射液心力衰竭心功能N一末端原脑利钠
3、肽InfluenceofShenfuInjectiononCardiacFunctionandContentofNT-proBNPinPatientswithChronicHeartFailureUHua—qin,HUYuan一u,ZHOUYu-ping,etGuang'anmenHospital,ChinaAcademyofChineseMedicalSciences(Beijing100053)【Abstract】Objective:ToobservetheInfluenceofShenfuInjectiononthecontentof
4、NT—proBNPandthecardiacfunctioninpatientswithchronicheartfailure.Methods:63patientsofchronicheartfailurecausedbycoronaryheartdiseasewererandomlydividedintothecontrolgroupwith32casesusedtheregulartreatmentandthetreatmentgroupwith31casesusedtheregulartreatmentandtheShenfuInje
5、ction.Aftersevendays,thelevelofNT-proBNPandthecardiacfunctionweredetected.Results:Aftertreatment,theLVEDD,theLVEF,theCOandtheFSwereimprovedobviouslythanthosebeforetreatmentinbothgroups.However,theseindicesinthetreatmentgroupwerebetterthanthoseinthecontrolgroup.Theselevelso
6、fNT—proBNPinbothgroupsweresignificantlydecreasedaftertreatment.Moreover,theinductiondegreeofthetreatmentgroupwasmoresignificantlythanthatofthecontrolgroup.Conclusion:ShenfuInjectioncansignificantlyenhancethecardiacsystolicanddiastolicfunctionanddecreasetheNT-proBNPleve1.【K
7、eywords】ShenfuInjection;Heartfailure;Cardiacfunction;N-terminal-pro-brainnatriureticpeptide参附注射液是治疗心力衰竭的常用中药注射剂之一,目前已有大量文献证实其治疗心力衰竭的有效性,但有关对N一末端原脑利钠肽(NT—proBNP)的影响少见报道.近年研究表明,血浆NT—proBNP与心功能关系极为密切,且比脑利钠肽(BNP)更能反映心功能受损的程度口].本研究以慢性心力衰竭患者为研究对象,观察参附注射液对心力衰竭患者血浆NT—proBNP水平及心功能的
8、影响.现报告如下.1资料与方法1.1临床资料选择2007年6月一2008年3月在本基金项目:首都医学发展基金资助项目(SF一2007一I一04)△通信作者?1207??临床研究?
