针刺镇痛相关受体及正电子配基研究进展

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1、针刺镇痛相关受体及正电子配基研究进展作者：王慧春,左传涛,管一晖【关键词】针刺镇痛;电针;受体;正电子发射断层扫描;放射性配基Asatraditionaltreatmentmethod,acupuncturecanbeelioratepathologicprocesses,andthecapitalapplicationisanalgesia.Manystudies,includingneurobiochemisitry,histopathologyandradioligandbindingassayofreceptor,

2、shoediatedbyvariousneurotransmitters,neuropeptides,modulatorsandreceptors［13］.Hoitedastheyalexperiments.Accordingtocharacteristicsofreceptorligandbindingdomains,positronemissiontomography(PET)receptorimaginghaditssuperiorityinrealtimelyinvestigatingthedistribut

3、ion(localization),quantity(density)andfunction(affinity)ofthetracereceptorsinvivoechanismofAAandpromotereasonableapplicationofacupunctureifthePETreceptorimagingshouldbeusedinAAresearch.Asagingtoselectthesuitableradioligand,therefore,thepresentarticlerevieentmethod

4、ofstimulationproducinganalgesia,acupuncturecanrelievepainbyactivatingthepainrelatedreceptorsinbrain,ajorneurochemicalsubstancesinvolvedinAA［1,2］.Opiatereceptors(ORs)arealanbrain,andthenformedtheconceptofthreegroupsofORs(μ,κ,δ).From1970s,manyEOPsorethanthirtyyears

5、,andfourclassesofORligandshavebeendeveloped,includingμ,κ,δ,OFQRandendomorphin(EM),DYN,ENK,orphaninFQ(OFQ)andtheirrespectiveprecursors［4］.ThepreviousstudiesofAAmechanismsfoundthatnaloxone,aμreceptorantagonist,couldpartiallyreversetheanalgesiceffectsofacupuncturein

6、mice［2］.ThelevelofβEPinhumancerebrospinalfluidinistrationofvariousspecificantagonistsorantiseraofORsubtypes,Han［5］uncoveredthat2and100HzEAinducedanalgesiaeffectsediatedbyμ/δandκreceptorsintheratspinalcordrespectivelyunderthephysiologicalpainconditions.Threeclasse

7、sofEOPs(μ、κandδ)couldbereleasedsimultaneouslybyusingloent［6］associatedmatorypaininratsinistrationofμandδreceptorantagonists.HoanifestedthatEAinducedtheanalgesiceffectsviaactivatingμandδreceptorsbutnoκreceptorunderthepathologicconditions,ainsmediatinghighandloalsp

8、ecies,typesofpain,routesanddosesofadministrationorsitesofactioninedbystimulatingthedifferentOFQRsubtypes［7］.1.2ORPETradioligands11Cdiprenorphine(DPN)an