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1、腺苷蛋氨酸联合熊去氧胆酸治疗妊娠期肝内胆汁淤积症的临床研究唐雍艳苏州第五人民医院妇产科江苏苏州215007目的分析腺苷蛋氨酸联合熊去氧胆酸治疗妊娠期内胆汁淤积症的临床效果.方法选择70例妊娠期内胆汁淤积症患者作为研宄对象，将随机分为对照组和观察组，每组35例.其屮对照组患者单纯使用腺苷蛋氨酸进行治疗，观察组患者采用熊去氧胆酸联合腺苻蛋氨酸联合熊去氧胆酸进行治疗.比较两组患者治疗前后血淸总胆酸(TBA)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、总胆红素(TB)变化情况，瘙痒评分得分情况以及妊娠结局.结果治疗后，所有患者的TBA、TB、
2、AST、ALT以及瘙痒评分与治疗前相比均显著降低(P<0.05);治疗后观察组患者的TBA、TB、AST、ALT以及瘙痒评分显著低于对照组患者(P<0.05);观察组患者发生羊水污染、早产、新生儿窒息、新生儿体重异常等情况发生率显著低于对照组患者(P<0.05).结论腺苻蛋氨酸联合熊去氧胆酸治疗妊娠期内胆汁淤积症的临床治疗效果显著，能够明显改善患者的妊娠结局，制的临床推广使用.【关键词】妊娠期；胆汁淤积症；熊去氧胆酸；腺苷蛋氨酸【Abstract】Objective:toanalysisofadenosinemethioninecomb
3、inedwithursodeoxycholicacidinthetreatmentofpregnancytheclinicaleffectofintrahepaticcholestasis.Methods:select70casesofpregnancyperiodcholestasispatientsastheresearchobject,wererandomlydividedintocontrolgroupandobservationgroup,35casesineachgroup-Patientsofthecontrolgroup
4、^atientsonlyademetioninetreatment,observationgrouppatientsweretreatedwithursodeoxycholicacidcombinedwithTransmetilcombinedbeardeoxycholicacid.Werecomparedbetweenthetwogroupsbeforeandaftertreatmentinpatientswithserumtotalbileacid(TBA),aspartateaminotransferase(AST),alanin
5、eaminotransferase(ALT),totalbileredhormone(TB),pruritusscoretoAndpregnancyoutcome.ReGsults:aftertreatment,allpatientswithTBATB,AST,ALTandpruritusscorebeforetreatmentcomparedweresignificantlydecreased(P<0.05);aftertreatGment,theobservationgroupofpatientswithTBATB,AST,ALTa
6、ndpruritusscorewassignificantlylowerthanthatofcontrolgroup(P<0.05);patientsintheobservationgroupoccurredamnioticfluidpollution,prematurebirth,neonatalasphyxia'neonatalweightabnormaloccurrenceratewassignificantlylowerthanthatofthecontrolgroup(P<0.05).Conclusion:adenosinem
7、ethioninecombinedwithursodeoxycholicacidinthetreatmentofpregnancywithremarkableeffect【koefytwhoerdcli】nicaltreatmentofintrahepaticcholestasistosignificantlyimprovetheriskofThepregnancyoutcome,theclinicaluseofthesystem.pregnancy;intrahepaticcholestasis;ursodeoxycholicacid
8、;s—ademetionineR454B1008—6315(2015)12—0152—02妊娠期内胆汁淤积症(ICP)是处于妊娠中期或者晚期的孕妇特冇的并发症，临床上患者主要变现出胆汁酸升高和皮肤瘙痒.IC
