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1、来曲哇和克罗米芬对于多囊卵巢综合征诱发排卵效果分析何玮1黄丽萨1郑洁1李俊林通讯作者绵阳市中心医院妇产科生殖医学中心四川绵阳621000【】目的：探讨促排卵药物对于多囊卵巢综合征（PCOS）诱发排卵效果。方法：选择PCOS患者85例随机分为两组，A组40例，共56个周期，口服克罗米芬（CC）;B组45例，共60个周期，口服来曲唑（LE）,均服用5天,分别检测卵泡大小、成熟卵泡数及人绒毛膜促性腺激素（HCG）注射H子宫内膜（Em）的厚度，并统计排卵率、妊娠率、卵巢过度刺激综合征（OHSS）和多胎率。结果：LE组患者成熟卵泡明显少于CC组、LE组HCG注射日子宫内膜平均厚度高于C
2、C组，卵泡未破裂黄素化现象（LUFS）、卵巢过度刺激综合征（OHSS）及多胎发生率LE组均低于CC组，而两者比较排卵率和周期妊娠率无明显差异。结论：第三代芳香化酶抑制剂-来曲唑有促使卵泡生K:的作用，且不影响子宫内膜生长，并能降低卵巢过度刺激综合征及多胎妊娠的风险，对克罗米芬反应不良患者有一定疗效。【关键词】来曲唑；克罗米芬；多囊卵巢综合征；诱发排卵【】R711.75【】B【】1764-8999（2015）7-0452-02TheTherapeuticEffectivenessofOvulationforPolycysticOvarySyndromewithLetrozole
3、andclomiphenecitrateHEWeil,HUANGLi-sal,ZHENGJiel,LIJun-linl1.ReproductiveMedicineCenter,MianyangCentralHospital,Mianyang,Sichuan621000.P.R.China【Abstract】Objective：Toinvestigatetheinducedovulationeffectofovulationdrugsforpolycysticovarysyndrome（PCOS）.Methods：85casesofPCOSpatientswererandoml
4、ydividedintotwogroups,40casesingroupA,takingoralclomiphenecitrate(CC)foratotalof56cycles,while45casesingroupB,takingoralletrozole(LE)foratotalof60cycles.Bothgroupsweretreatedfor5daysthefollicularsize,thenumberofmaturefolliclesandthedayofHCGinjectionofuterusthethicknessoftheendometrium(Em)we
5、redetectedandtheovulationrate,ovarianhyperstimulationsyndrome(OHSS),pregnancyrateandmultiplepregnancyratewerecalculated.Results：NumberofmaturefolliclesofpatientsintheLEgroupwaslargerthanthoseintheCCgroup.ThematurefollicleofpatientsintheLEgrouponthedayofHCGinjectionwaslessthanCCgroup,endomet
6、rialthicknessinLEgroupwasbiggerthanthatinCCgroup,thephenomenonofluteinizedunrupturedfollicle(LUFS),ovarianhyperstimulationsyndrome(OHSS)andtheincidenceofmultiplepregnanciesinLEgroupwaslowerthanthatinCCgroup,whilethecomparisonbetweenthetwoovulationrateandpregnancyrateofnoobviousdifference.Co
7、nclusion：Thethirdgenerationaromataseinhibitorsletrozolehaspromptedthefolliclegrowth,anddoesnotaffectthegrowthoftheendometrium.Itcanreducetheriskofovarianhyperstimulationsyndromeandmultiplepregnancies,havecertaincurativeeffectonpatientswithadversereaction
