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1、Histopathology2007,50,289310.DOI:10.1111/j.1365-2559.2006.02546.xREVIEWPathologicaldiagnosisofgranulomatouslungdisease:areviewOAEl-Zammar&A-LAKatzensteinDepartmentofPathology,SUNYUpstateMedicalUniversity,Syracuse,NY,USAEl-ZammarOA&KatzensteinA-LA(2007)Histopathology50,289310Pathological
2、diagnosisofgranulomatouslungdisease:areviewGranulomasinthelungarecommondiagnosticsummarizesthemainhistologicalfeaturesthathelpproblemsencounteredbypathologists.Theyoccurindistinguishvariousgranulomatouslungdiseases.Itawiderangeofpulmonaryconditions,rangingfromconcentratesonthemostimport
3、antandcommoncommonentitiestouncommononesandincludingentitiesthatmaybeencounteredandemphasizesbothinfectionsandnon-infectiousdiseases.Thisreviewhelpfulfeaturesinthedifferentialdiagnosis.Keywords:granulomatouslungdisease,lunggranuloma,sarcoidosis,tuberculosis,WegenersgranulomatosisAbbrevi
4、ations:BOOP,bronchiolitisobliteransorganizingpneumonia;C-ANCA,cytoplasmicantineutrophilcytoplasmicantibodies;FM,FontanaMasson;GMS,Gomorimethenaminesilver;H&E,haematoxylinandeosin;Mac,Mycobacteriumaviumcomplex;P-ANCA,perinuclearantineutrophilcytoplasmicantibodies;PAS,periodicacid-Schiff;
5、PCR,polymerasechainreaction;TB,TuberculosisIntroductioneredtobehistologicallydifferentfromcaseating,inthatremnantsoflungparenchymaorinflammatoryTheevaluationofgranulomatouslunglesionsisacellsmaybefoundintheformerandareabsentinthecommontaskforthesurgicalpathologist.Microbiolo-latter.Wehav
6、enotfoundthisdistinctionusefulandwegicalculturesareimportantforidentifyinginfectioususethetermsinterchangeably.Sincecaseatingrefersagents,butculturesarefrequentlynotperformed,oriftoagross,cheesyappearance,weprefernecrotizingthepatientisacutelyilladiagnosismaybeneededforthemicroscopiccha
7、nges.beforetheresultsofculturesareknown.Thepathol-Infectionsusuallycausenecrotizinggranulomasoraogistthereforemustbeabletoestablishadiagnosiscombinationofnecrotizingandnon-necrotizinggra-fromexaminationofroutinehistologicalandspeciallynulomas,althoughsomeorganisms,suchasCrypto-
