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1、Sleepapneaandfattyliverdisease:ThegrowinglinkandmanagementissuesSuryaPrakashBhatt,RandeepGuleriaCITATIONBhattSP,GuleriaR.Sleepapneaandfattyliverdisease:Thegrowinglinkandmanagementissues.WorldJRespirol2014;4(2):11-18URLhttp://www.wjgnet.com/2218-6255/full/v4/i2/11.htmDOIhttp://dx.doi.org/10.5
2、320/wjr.v4.i2.11OPENACCESSArticlespublishedbythisOpen-AccessjournalaredistributedunderthetermsoftheCreativeCommonsAttributionNon-commercialLicense,whichpermitsuse,distribution,andreproductioninanymedium,providedtheoriginalworkisproperlycited,theuseisnoncommercialandisotherwiseincompliancewit
3、hthelicense.CORETIPObstructivesleepapnea(OSA)isassociatedwithnonalcoholicfattyliverdisease(NAFLD)inanimalsandhumans.Importantly,OSAcanaggravatethedevelopmentofNAFLDtononalcoholicsteatohepatitisinobeseindividuals.OSAhasalsobeenlinkedtootherfeaturesofthemetabolicsyndrome,includingdyslipidemia,
4、insulinresistanceandhypertension.Awidevarietyofintermediatephenotypesandgenesareinvolvedinsleepapneaandfattyliverwhichmakesthissyndromegeneticallycomplex.LifestyleinterventionshouldbefirstlinetreatmentforallNAFLDandOSApatients.Severaldrugsaimtoimprovemetabolicsyndromebutneedfurtherinvestigat
5、ion.Bariatricsurgerymayimproveconditionsassociatedwithmetabolicsyndrome,OSAandNAFLDinthemorbidlyobese.KEYWORDSBodymassindex;Inflammation;AsianIndian;Insulinresistance;MetabolicsyndromeCOPYRIGHT©2014BaishidengPublishingGroupInc.Allrightsreserved.COPYRIGHTLICENSEOrderreprintsorrequestpermissio
6、ns:bpgoffice@wjgnet.comNAMEOFWorldJournalofRespirologyJOURNALISSN2218-6255(online)PUBLISHERBaishidengPublishingGroupInc,8226RegencyDrive,Pleasanton,CA94588,USAWEBSITEhttp://www.wjgnet.comESPSManuscriptNO:7299Columns:REVIEWSleepapneaandfattyliverdisease:ThegrowinglinkandmanagementissuesSuryaP
7、rakashBhatt,RandeepGuleriaSuryaPrakashBhatt,RandeepGuleria,DepartmentofPulmonaryMedicineandSleepDisorders,AllIndiaInstituteofMedicalSciences,NewDelhi110029,IndiaAuthorcontributions:BhattSPandGuleriaRbothcontributedtothispaper.Correspondenceto:Surya
