Effect-of-specific-amino-acids-on-hepatic-lipid-metabolism-in-fructose-induced-non-alcoholic-fatty-liver-disease_2016_Clinical-Nutrition

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1、ClinicalNutrition35(2016)175e182ContentslistsavailableatScienceDirectClinicalNutritionjournalhomepage:http://www.elsevier.com/locate/clnuOriginalarticleEffectofspecificaminoacidsonhepaticlipidmetabolisminfructose-inducednon-alcoholicfattyliverdiseaseaaabPrasanthiJegatheesan,

2、StephanieBeutheu,GabrielleVentura,GillesSarfati,accdEstherNubret,NathalieKapel,Anne-JudithWaligora-Dupriet,InaBergheim,a,ba,b,*LucCynober,Jean-PascalDe-BandtaNutritionBiologyLaboratory,EA4466,FacultyofPharmacy,ParisDescartesUniversity,SorbonneParisCite,Paris,FrancebClinic

3、alChemistryDepartment,HopitauxUniversitairesParisCentre,APHP,Paris,France^cMicrobiology,EA4065,FacultyofPharmacy,ParisDescartesUniversity,SorbonneParisCite,Paris,FrancedInstitutofNutrition,SDModelSystemsofMolecularNutrition,Friedrich-SchillerUniversityJena,Jena,Germanyarti

4、cleinfosummaryArticlehistory:Background&aim:FructosedietshavebeenshowntoinduceinsulinresistanceandtoalterliverReceived14October2014metabolismandgutbarrierfunction,ultimatelyleadingtonon-alcoholicfattyliverdisease.Citrulline,Accepted29January2015GlutamineandArgininemayimprov

5、einsulinsensitivityandhavebeneficialeffectsonguttrophicity.Ouraimwastoevaluatetheireffectsonliverandgutfunctionsinaratmodeloffructose-inducednon-Keywords:alcoholicfattyliverdisease.CitrullineMethods:MaleSpragueeDawleyrats(n¼58)receiveda4-weekfructose(60%)dietorstandardchowGl

6、utaminewithorwithoutCitrulline(0.15g/d)oranisomolaramountofArginineorGlutamine.AlldietswereArgininemadeisonitrogenousbyadditionofnon-essentialaminoacids.Atweek4,nutritionalandmetabolicNon-alcoholicfattyliverdiseasestatus(plasmaglucose,insulin,cholesterol,triglyceridesandami

7、noacids,netintestinalabsorption)wasdetermined;steatosis(hepatictriglyceridescontent,histologicalexamination)andhepaticfunction(plasmaaspartateaminotransferase,alanineaminotransferase,alkalinephosphatase,bilirubin)wereassessed;andgutbarrierintegrity(myeloperoxidaseactivity,p

8、ortalendotoxemia,tightjunctionproteinexpressionandlocalization)andintestinalandhep