prophylactic use of fluconazole in neutropnic cancer patients

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1、Downloadedfrompmj.bmj.comonOctober24,2012-Publishedbygroup.bmj.comPostgradMedJ71995;71:284-286C)TheFellowshipofPostgraduateMedicine,1995OriginalarticlesProphylacticuseoffluconazoleinneutropeniccancerpatientsKadriYamaq,Esin$enol,RaufHaznedarSummarybelow2000/41.Themeanneutroph

2、ilcountsThisstudywascarriedouton70patientswere822±645/il(range0-1908/tl).withhaematologicalorsolidmalignan-Patientswererandomlyassignedtoreceivecieswhowerereceivingchemotherapyornottoreceiveprophylaxiswithfluconazole.and/orradiotherapy.Forty-onepatientsProphylaxiswasgivento4

3、1patients;29wererandomlyassignedtoreceivefluc-patientsdidnotreceiveanyprophylaxis.onazole,400mg/day,whiletheywereFluconazolewasgivenorallyinadoseofneutropenic.Systemicfungalinfection400mgdailyintwodivideddoses.Treatmentdevelopedinfourofthe41patients(9%)wascontinueduntilthene

4、utrophilcounthadreceivingprophylaxisincomparisontoincreasedto2000/41oruntilsystemicfungalnineof29patients(31%)notreceivinginfectionwassuspected.Duringthetreatmentprophylaxis.Theincidenceofsystemicperiodculturesofthroat,feces,urineandbloodfungalinfectionwassignificantlydiffer

5、-wereobtainedtwiceweekly.Inaddition,entbetweenthegroupsreceivingpro-patientswereevaluatedforsignsandsymptomsphylaxisandthosenotreceivingit(p

6、fungalinfec-wasisolatedfrombloodorurineandwhentionsinneutropenicpatientswithcancer.yeastsandpseudohyphaeweremicroscopicallyseenonsterileurinesmears.Keywords:fluconazole,prophylaxis,fungalinfectionSTATISTICALANALYSISStudent'sunpairedt-testwasusedforcom-parisonofvariables,eg,a

7、bsoluteneutrophilIntroductioncounts.Nominalresults,eg,incidenceofCan-didainfection,betweengroupswerecomparedFungalinfectionsarebecominganincreasingusingthechi-squaredtest.Ap-valuebelowproblemincancerpatientsandfactorsthatplay0.05wasconsideredsignificant.Dataareanimportantrol

8、einthisincreaseincludereportedasmean±standarddeviation(SD).difficultiesines