资源描述：
《Adherence Patterns for Abiraterone Acetate and Concomitant Prednisone Use in Patients with Prostate Cancer.PDF》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、RESEARCHAdherencePatternsforAbirateroneAcetateandConcomitantPrednisoneUseinPatientswithProstateCancerMarie-HélèneLafeuille,MA;AmandaMelinaGrittner,MA;PatrickLefebvre,MA;LorieEllis,PhD;R.ScottMcKenzie,MD;TerraSlaton,MS;andChrisKozma,PhDABSTRACTWhatisalreadyknownaboutthissubjectBACKGROUND:W
2、iththegrowinguseoforalanticancermedications,under-standingadherencepatternshasbecomeincreasinglyimportant.Abiraterone•Oralanticancermedicationshavebecomemorewidelyavailableacetate(AA)isaprodrugofabiraterone,anovelandrogenbiosynthesisinhib-forthetreatmentofabroadnumberofcancersandhaveincre
3、as-itor.AAisapprovedforuseincombinationwithprednisonefortreatmentofinglybeenusedasanalternativetointravenoustherapy.patientswithmetastaticcastration-resistantprostatecancer.•Inordertobeequallyeffectiveasintravenoustherapies,suchoralOBJECTIVE:ToevaluateAAandconcomitantprednisoneutilization
4、andtreatmentsrequirethatpatientssufficientlyadheretoprescrip-adherencepatternsforpatientswithprostatecancerintheUnitedStates.tionguidelines.METHODS:Thisstudyuseddatafrom2administrativehealthcareclaims•Adherencetoanticancermedicationregimenshasbeenfoundtodatabases—Dataset1:TruvenHealthAnal
5、yticsMarketScan(Decemberbedifficulttopredictandtovarywidelybetween16%and100%.2010toAugust2012)andDataset2:SymphonyHealthSolutions’ProMetisLx(June2009toMarch2013).Toevaluatetheconsistencyofmedication-Whatthisstudyaddstakingbehavior,adherencewasmeasuredusingmedicationpossessionratio(MPR),wh
6、ichwascalculatedasthesumofdaysofsupplydividedby•Thisstudyevaluatedutilizationandadherencepatternsforthedaysontherapyinpatientswithatleast2AAprescriptions.Additionalabirateroneacetate—whichisaprodrugforabiraterone,anoveloutcomesincludedtheproportionofpatientstakingprednisone,meanandrogenbi
7、osynthesisinhibitor—andforconcomitantpredni-andmediandailydoseofAA,andconcomitantprednisoneuse.AdherencesoneuseinpatientswithprostatecancerintheUnitedStates.wasalsostudiedbyage,healthcareplantype,orpreviousrecentchemo-therapysubgroups.•Itwasfoundthatthevastmajorityo
