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1、PracticalguidetotheuseofabirateroneincastrationresistantprostatecancerElaheA.Mostaghel,MD,1,2DanielW.Lin,MD31DivisionofClinicalResearch,FredHutchinsonCancerResearchCenter,Seattle,Washington,USA2DivisionofMedicalOncology,UniversityofWashington,SeattleWashington,USA3DepartmentofUrology,UniversityofWa
2、shington,Seattle,Washington,USAMOSTAGHELEA,LINDW.Practicalguidetotheandmonitoringrequirements,andconcludebydiscussinguseofabirateroneincastrationresistantprostatefuturedirectionsintheuseofabiraterone,includingcancer.CanJUrol2014;21(Suppl1):57-63.earlydatasupportinganexpandedroleforabirateroneincast
3、rationsensitivedisease.Introduction:WhileandrogendeprivationtherapyResults:Accumulatingdataemphasizethat‘androgenremainstheprimarytreatmentmodalityforpatientswithindependent’or‘hormonerefractory’tumorsremainmetastaticprostatecancer,treatmentisuniformlymarkedsensitivetohormonalactivationandsuggestth
4、atdespitebyprogressiontocastrationresistantprostatecancersuppressionofcirculatingtestosterone(T),residualtumor(CRPC).AbirateroneisthefirstnewdrugtoenterclinicalandrogensplayaprominentroleinmediatingCRPCpracticeinaseriesofnovelagentsdesignedtopotentlyprogression.targetadrenalandtumorandrogenproducti
5、on.Conclusions:Accordingly,therapeuticstrategiessuchMaterialsandmethods:Herein,wereviewtheabirateronethatmoreeffectivelytargetproductionofmechanismofactionofabirateroneandthephaseIIIintratumoralandrogensarenecessary.datasupportingitsapprovalforpatientswithmetastaticCRPC.Wediscusspracticaltreatmentc
6、onsiderations,KeyWords:castrationresistantprostatecancer,includingtheincidenceandmanagementofsideeffectintratumoralandrogen,CYP17A,abirateroneIntroductionactivationandsuggestthatdespitesuppressionofcirculatingtestosterone(T),residualtumorandrogensTheefficacyofandrogendeprivationtherapy(ADT)isplayap
7、rominentroleinmediatingCRPCprogression.5routinelybasedonachievingcastratelevelsofserumT,EmergingdatasuggestresidualintratumoralandrogensarbitrarilydefinedasT≤20or50ng/dL.However,areproducedviatheuptakeandco
