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1、DrugProfileTheeconomicsofabirateroneacetateforcastration-resistantprostatecancerExpertRev.Pharmacoecon.OutcomesRes.14(2),175–179(2014)AthanasiosDellis1,2Abirateroneacetateisanoralmedicationthathasrecentlybeengrantedapprovalfortheandtreatmentofmetastaticcastrationresistantprostatecancer(mCRPC)pri
2、orand/orafterAthanasiosGchemotherapywithdocetaxel.Inthisarticleweassesstheeconomicsofabirateroneacetate1,3–5inmCRPC.RelevantstudiesdemonstratedthatabirateroneacetatehadaminimalbudgetPapatsoris*impactonhealthplans.Arelevantadvantagewasthecostsavingsduetothelackof1UniversityDepartmentofUrology,che
3、motherapy-relatedsideeffectsaswellastheeaseofadministration.Theresultsofcost/SismanoglioGeneralHospital,Athens,benefitcomparativestudieswithothernovelagents(i.e.cabazitaxel,enzalutamide,Greece2UniversityDepartmentofGeneralsipuleucel-T)arewarrantedaswellastheclosecollaborationbetweenurologistsand
4、medicalSurgery,AreteionHospital,Athens,oncologists.Greece3HellenicGroupofGenitourinaryKEYWORDS:abirateroneacetate•castrationresistant•cost/benefit•economics•metastatic•prostatecancerCancer,Athens,Greece4DepartmentofUrology,BartsandTheLondonNHSTrust,London,UKProstatecancer(PC)remainsthemostcom-no
5、veloralmedication,whichisabiraterone5InstituteofMolecularMedicineandBiomedicalResearch,Athens,GreecemonnoncutaneouscancerintheWesternacetate.*Authorforcorrespondence:world.IntheUSA,PC-relatedexpendituresTel.:+302108044703wereUS$9.9billionin2006andinflatedtoAbirateroneacetateusageagpapatsoris@yah
6、oo.grUS$11.9billionin2012,makingPCthefifthAbirateroneacetateisfirst-in-classlyaseinhibi-mostcostlycancer[1].GiventhesignificanttorofcytochromeP-450c17,acriticalenzymeannualcostoftreatingPC,healthplanbudgetinextragonadalandtesticularandrogensynthe-holdersshouldbecognizantofthefinancialsis[4,5].It
7、representsanimprovementofketo-impactofnewandexpensivetreatmentsofconazolethatisnolongerusedoravailable.PC,especiallyofmetastaticcastration-resistantByblockingcytochromeP-450c17,abirateronePC(mCRPC).acetatesignificantlydecrea
