polyunsaturated fatty acids reduces post-operative atrial fibrillation incid

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1、MonaldiArchChestDis2011;76:93-98CASEREPORTN-3polyunsaturatedfattyacidsreducespost-operativeatrialfibrillationincidenceinpatientsundergoing“on-pump”coronaryarterybypassgraftsurgeryIN-3PUFAriduconol’incidenzadifibrillazioneatrialepost-operatorianeipazientisottopostiallarivascolariz

2、zazionechirurgicaincircolazioneextracorporeaMarioSorice1,FrancescoPaoloTritto1,ChiaraSordelli2,RosarioGregorio1,LuigiPiazza1ABSTRACT:N-3polyunsaturatedfattyacidsreducespost-Results:Theoverallincidenceofpost-operativeatrialoperativeatrialfibrillationincidenceinpatientsundergoingfi

3、brillationwas17.4%(35/201).Thearrhythmiaoccurredin“on-pump”coronaryarterybypassgraftsurgery.M.Sorice,11.4%(11/96)ofthepatientsintherapywithn-3polyunsat-F.P.Tritto,C.Sordelli,R.Gregorio,L.Piazza.uratedfattyacidsandin22.8%(24/105)inthecontrolBackground:Theaimofthisstudywastoevaluat

4、ethegroups.Inparticular,thestatisticalanalysisofsubgroupsefficacyofpreoperativeandpostoperativetherapywithn-3showedasignificantreductionofpostoperativeatrialfibril-polyunsaturatedfattyacidsinreducingtheincidenceoflationonlyinthegroupincludingpatientstreatedwithn-3atrialfibrillati

5、onaftercoronaryarterybypassgraftsurgery.polyunsaturatedfattyacidsundergoing“on-pump”coro-Methods:201patientsundergoingcoronaryarteryby-naryarterybypassgraftsurgery.Thelengthofhospitalstaypassgraftsurgerywererandomizedto1)acontrolgroupdidnotdifferamongallgroups.(105patients),or2)n

6、-3polyunsaturatedfattyacids2g/dayConclusions:N-3polyunsaturatedfattyacidsadminis-group(96patients)foratleast5daysbeforesurgeryandun-trationsignificantlyreducestheincidenceofpost-operativetilhospitaldischarge.Groupswerefurthersubdividedinfouratrialfibrillationinpatientsundergoing“

7、on-pump”coro-subgroupsaccordingtotheoperativetechnique:“off-pump”naryarterybypassgraftsurgery.N-3polyunsaturatedfattyor“on-pump”.Theprimaryendpointwastoevaluatethere-acidstherapyisnotassociatedwithashorterhospitalstay.ducedincidenceofpostoperativein-hospitalatrialfibrillationKeyw

8、ords:heartbypass,coronaryarterybypass,of