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1、ThenewenglandjournalofmedicineoriginalarticleIrbesartaninPatientswithAtrialFibrillationTheACTIVEIInvestigators*AbstractBackgroundThemembersofthewritinggroup(SalimTheriskofcardiovasculareventsamongpatientswithatrialfibrillationishigh.Yusuf,M.B.,B.S.,D.Phil.,JeffS.Healey,Weevaluatedwhe
2、therirbesartan,anangiotensin-receptorblocker,wouldreduceM.D.,JanicePogue,M.Sc.,SusanChro-thisrisk.lavicius,R.N.,MarcusFlather,M.B.,B.Ch.,RobertG.Hart,M.D.,StefanH.Hohn-loser,M.D.,CampbellD.Joyner,M.D.,MethodsMarcA.Pfeffer,M.D.,andStuartJ.Con-Werandomlyassignedpatientswithahistoryofri
3、skfactorsforstrokeandasystolicnolly,M.D.),assumeresponsibilityfortheoverallcontentandintegrityofthearti-bloodpressureofatleast110mmHgtoreceiveeitherirbesartanatatargetdoseofcle.AddressreprintrequeststoDr.Yusuf300mgoncedailyordouble-blindplacebo.Thesepatientswerealreadyenrolledinatthe
4、PopulationHealthResearchInsti-oneoftwotrials(ofclopidogrelplusaspirinversusaspirinaloneorversusoralanti-tute,DavidBraleyCardiac,VascularandStrokeResearchInstitute,HamiltonHealthcoagulants).Thefirstcoprimaryoutcomewasstroke,myocardialinfarction,ordeathSciencesandMcMasterUniversity,237
5、fromvascularcauses;thesecondwasthiscompositeoutcomeplushospitalizationBartonSt.East,Hamilton,ONL8L2X2,forheartfailure.Canada,oratyusufs@mcmaster.ca.*TheAtrialFibrillationClopidogrelTrialResultswithIrbesartanforPreventionofVascu-Atotalof9016patientswereenrolledandfollowedforameanof4.1
6、years.ThemeanlarEvents(ACTIVEI)investigatorsarelistedintheSupplementaryAppendix,reductioninsystolicbloodpressurewas2.9mmHggreaterintheirbesartangroupavailableatNEJM.org.Theaffiliationsthanintheplacebogroup,andthemeanreductionindiastolicbloodpressurewasofthewritinggrouparelistedinthe1
7、.9mmHggreater.Thefirstcoprimaryoutcomeoccurredatarateof5.4%perAppendix.100person-yearsinbothgroups(hazardratiowithirbesartan,0.99;95%confi-NEnglJMed2011;364:928-38.denceinterval[CI],0.91to1.08;P=0.85).ThesecondcoprimaryoutcomeoccurredCopyright©2011MassachusettsMedicalSociety.atarateo
8、f7.3%per100p
