assesment of polyunsaturated fatty acids in cord blood of infants of diabetic mothers

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1、Assesmentofpolyunsaturatedfattyacidsincordbloodofinfantsofdiabeticmothers×÷ÕߣºGalilaMMokhar,SohaMAbdElDayem,NermineHSayed,SohairabdElMaksod,ManalElShamaa,HaniMElMikaty]¡¾ÕªÒª¡¿Objective:Toassesswhetherinfantsofdiabeticmothers[prepregnancydiabetics(PPD)andgestationaldiabeticsmellitus(GDM)]hav

2、ecompromisedarachidonicanddocosahexaenoicacidsintheirplasmaandtherelationshipwithdeficiencyofthesamecompoundsintheirmothers.Methods:Thisstudywasconductedon30diabeticmothers(bothPPDandGDM)andtheirinfants.Twentyhealthyinfantsandtheirmotherswithageandsexmatchedwereincludedascontrols.Allinfant(of

3、diabeticandnondiabeticmothers)weresubjectedtoassessmentofAPGARScoring,thoroughhistorytakingandanthropometricmeasures.Lipidprofilecomponentsaswellaspolyunsaturatedfattyacids(PUFA)wereassessedindiabeticGDMandPPDandnondiabeticmothersaswellasintheirbabies.Results:Highª²densitylipoproteir(HDL)leve

4、lwasfoundtobesignificantlylowerindiabeticmothers(speciallythosewithPPD)comparedtonondiabeticones,whereasnosignificant8differencewasfoundbetweenbabiesofthetwogroups.Also,thecurrentstudyrevealedthatdiabeticmothers(GDMandPPD)andtheirbabieshadsignificantlyhigherlevelsofPUFAprecursorslinoleicacids

5、(LA)andalphalinoleicacids(ALA).PUFAarachidonicacid(AA)anddocosahexaenoicacids(DHA)werefoundtobesignificantlylowerindiabeticmothers(GDMandPPD)comparedtonondiabeticmothers,andsameresultswerefoundinthebabiesofthetwogroups.Conclusion:Neonateswithdiabeticmothers(bothGDMandPPD)havehighlycompromised

6、plasmalevelsofAAandDHAPUFA,whichaffectsthechildwellbeingbyfar,andproduceshazardousmultiª²systemcomplicationsonthelongrun.¡¾¹Ø¼ü´Ê¡¿Polyunsaturatedfattyacid;Arachidonicacid;Docosaª²hexaenoicacid;Diabetic;Infant;MotherINTRODUCTION¡¡¡¡Longª²chainpolyunsaturatedfattyacids(PUFA)[arachidonicacid(AA

7、)anddocosahexaenoicacids(DHA)]areessentialforoptimumfetalgrowthanddevelopment.Theyrepresentmajorcomponentsofthedevelopingcentralnervous8system,andareessentialforcognitiveandvisualfunctions[1].Theirconsumptionmayreducetheriskforavarietyofdisea