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ID:15183967
大小:31.00 KB
页数:8页
时间:2018-08-01
《assesment of polyunsaturated fatty acids in cord blood of infants of diabetic mothers》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、Assesmentofpolyunsaturatedfattyacidsincordbloodofinfantsofdiabeticmothers×÷ÕߣºGalilaMMokhar,SohaMAbdElDayem,NermineHSayed,SohairabdElMaksod,ManalElShamaa,HaniMElMikaty]¡¾ÕªÒª¡¿Objective:Toassesswhetherinfantsofdiabeticmothers[prepregnancydiabetics(PPD)andgestationaldiabeticsmellitus(GDM)]hav
2、ecompromisedarachidonicanddocosahexaenoicacidsintheirplasmaandtherelationshipwithdeficiencyofthesamecompoundsintheirmothers.Methods:Thisstudywasconductedon30diabeticmothers(bothPPDandGDM)andtheirinfants.Twentyhealthyinfantsandtheirmotherswithageandsexmatchedwereincludedascontrols.Allinfant(of
3、diabeticandnondiabeticmothers)weresubjectedtoassessmentofAPGARScoring,thoroughhistorytakingandanthropometricmeasures.Lipidprofilecomponentsaswellaspolyunsaturatedfattyacids(PUFA)wereassessedindiabeticGDMandPPDandnondiabeticmothersaswellasintheirbabies.Results:Highª²densitylipoproteir(HDL)leve
4、lwasfoundtobesignificantlylowerindiabeticmothers(speciallythosewithPPD)comparedtonondiabeticones,whereasnosignificant8differencewasfoundbetweenbabiesofthetwogroups.Also,thecurrentstudyrevealedthatdiabeticmothers(GDMandPPD)andtheirbabieshadsignificantlyhigherlevelsofPUFAprecursorslinoleicacids
5、(LA)andalphalinoleicacids(ALA).PUFAarachidonicacid(AA)anddocosahexaenoicacids(DHA)werefoundtobesignificantlylowerindiabeticmothers(GDMandPPD)comparedtonondiabeticmothers,andsameresultswerefoundinthebabiesofthetwogroups.Conclusion:Neonateswithdiabeticmothers(bothGDMandPPD)havehighlycompromised
6、plasmalevelsofAAandDHAPUFA,whichaffectsthechildwellbeingbyfar,andproduceshazardousmultiª²systemcomplicationsonthelongrun.¡¾¹Ø¼ü´Ê¡¿Polyunsaturatedfattyacid;Arachidonicacid;Docosaª²hexaenoicacid;Diabetic;Infant;MotherINTRODUCTION¡¡¡¡Longª²chainpolyunsaturatedfattyacids(PUFA)[arachidonicacid(AA
7、)anddocosahexaenoicacids(DHA)]areessentialforoptimumfetalgrowthanddevelopment.Theyrepresentmajorcomponentsofthedevelopingcentralnervous8system,andareessentialforcognitiveandvisualfunctions[1].Theirconsumptionmayreducetheriskforavarietyofdisea
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