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pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells

pentachlorophenol decreases tumor-cell-binding capacity and cell-surface protein expression of human natural killer cells

ID：7290216

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页数：8页

时间：2018-02-10

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1、ResearchArticleReceived:23August2011,Revised:4October2011,Accepted:27October2011PublishedonlineinWileyOnlineLibrary:22December2011(wileyonlinelibrary.com)DOI10.1002/jat.1781Pentachlorophenoldecreasestumor-cell-bindingcapacityandcell-surfaceproteinexpressio

2、nofhumannaturalkillercellsabaTasiaHurd,JasmineWalkerandMargaretM.Whalen*ABSTRACT:Pentachlorophenol(PCP)isanorganochlorinepesticidethatdecreasesthetumor-cellkilling(lytic)functionofhumannaturalkiller(NK)cells.NKcellsdefendagainsttumorcellsandvirallyinfected

3、cells.Theybindtothesetargets,utilizingavarietyofcell-surfaceproteins.ThisstudyexaminedconcentrationsofPCPthatdecreaselyticfunctionforalter-ationofNKbindingtotumortargets.LevelsofPCPthatcausedlossofbindingfunctionwerethenexaminedforeffectsonexpressionofcell

4、-surfaceproteinsneededforbinding.Exposureto10mMPCPfor24h(whichcausedagreaterthan70%lossoflyticfunction)decreasedNKbindingfunction(34.6%),andCD11a(21.7%)andCD56(26.2%)cell-surfaceproteins.Bothbindingfunctionandcell-surfaceproteinsweredecreasedafterlongerexp

5、osurestolowerconcentrationsofPCP.ThesedataindicatethatcontinuousexposurestoPCPdecreasedbindingfunctionaswellascell-surfacemarkerexpressioninNKcellsandthatthesechangesmayinpartexplainthelossesoflyticfunctionseenwiththeseexposures.PCPexposureshavebeenshownto

6、increasetheincidenceofbloodandkidneycancersinhumans.ThesedataindicatethatapossibleexplanationforthisincreasedriskmaybelossofNKlyticfunction,whichisatleastinpartowingtothelossoftheabilityoftheNKcelltobindtotumorcells.Thesedataalsoindicatethatlostbindingfunc

7、tionmaybeduetolossofimportantcell-surfaceproteins.Copyright©2011JohnWiley&Sons,Ltd.Keywords:pentachlorophenol;NKcells;bindingfunction;CD16;CD56INTRODUCTIONmolecule,hasbeenimplicatedinactivationofthecytotoxicsignalingresponse(Lotzova,1993).CD16hasaroleasact

8、ivatingNaturalkiller(NK)cellspreventthedevelopmentaswellasthereceptoroftheNKlyticprocesswithantibody-coated(Lotzova,metastasesoftumors(Lotzova,1993;Vivieretal.,2004).Theyalso1993)andtumortargets(Mandelboimeta

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