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1、Downloadedfromhttp://cshperspectives.cshlp.org/atHunanNormalUniversityonOctober29,2012-PublishedbyColdSpringHarborLaboratoryPressNaturalKillerCellTolerance:ControlbySelforSelf-Control?BaptisteN.JaegerandEricVivierColdSpringHarbPerspectBiol2012;doi:10.1101/cshperspect.a007229SubjectCollectionI
2、mmuneToleranceTregCells,LifeHistory,andDiversityT-CellTolerance:CentralandPeripheralChristopheBenoistandDianeMathisYanXingandKristinA.HogquistInfectious(Non)tolerance--FrustratedCentralB-CellTolerance:WhereSelectionBeginsCommensalismGoneAwry?RobertaPelandaandRaulM.TorresJesseC.NussbaumandRich
3、ardM.LocksleyHistoricalOverviewofImmunologicalToleranceTheImmunogeneticArchitectureofAutoimmuneRonaldH.SchwartzDiseaseAnGorisandAdrianListonNaturalKillerCellTolerance:ControlbySelforSelf-Control?BaptisteN.JaegerandEricVivierForadditionalarticlesinthiscollection,seehttp://cshperspectives.cshlp
4、.org/cgi/collection/Copyright©2012ColdSpringHarborLaboratoryPress;allrightsreservedDownloadedfromhttp://cshperspectives.cshlp.org/atHunanNormalUniversityonOctober29,2012-PublishedbyColdSpringHarborLaboratoryPressNaturalKillerCellTolerance:ControlbySelforSelf-Control?BaptisteN.Jaeger1,2,3andEr
5、icVivier1,2,3,41CentredImmunologiedeMarseille-Luminy,Universite´delaMe´diterrane´eU631,CampusdeLuminycase906,13288Marseille,France2INSERMUMR-S631,Marseille,France3CNRS,UMR6102,Marseille,France4AssistancePubliqueHopitauxdeMarseille,HopitaldelaConception,13385Marseille,FranceCorrespondence:bjae
6、ger@ciml.univ-mrs.frAmajorchallengefortheimmunesystemistocontrolpathogensandstressedcells,suchasinfectedortumorscells,whilesparinghealthyself-cells.Toachievethistolerancetoself,immunecellsmustrecognizeanddifferentiateselfversusnonselfandselfversusalteredself.Intheabsenceofself-tolerance,cells
7、oftheadaptiveimmunesystemattackhealthycellsandcauseautoimmunediseasessuchaslupus,psoriasis,andtypeIdiabetes.Mechanismsatworktoensuretoleranceintheinnateimmunesystemarestillpoorlyunder-stood.Naturalkillercellsareinnateimmunelymphocytes,whichha
