最新眼用制剂【精品-】教学讲义PPT课件.ppt

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1、眼用制剂【精品-】第七节眼用制剂滴眼剂(Eye-drop)为直接用于眼部的外用液体制剂。以水溶液为主，包括少数水性混悬液，也有将药物做成片剂，临用时制成水溶液。眼用液体药剂按用法可分为滴眼剂及洗眼剂。工业生产只有滴眼剂。滴眼剂的质量要求1.pH值正常眼可耐受的pH为5.0～9.0。pH6～8时无不舒适感觉，小于5.0和大于11.4有明显的感觉。2.渗透压眼球能适应的渗透压范围相当于浓度为0.6%～1.5%的氯化钠溶液，超过2%就有明显的不适。(二)影响吸收的因素1.药物从眼睑缝隙的损失2.药物外周血管消除3.pH与pKa4.刺激性5.表面

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