最新Design and Data Analysis in Cancer Research教学讲义PPT.ppt

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1、DesignandDataAnalysisinCancerResearchStudyProtocolResearchquestionSignificancebackgroundStudydesignStudypopulationandsamplingVariablesandmeasurementsStatisticalissuesEthicalissuesQualitycontrolanddatamanagement8/2/20212TheResearchCycleDevelopresearchquestionDesignst

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3、come8/2/20217DescriptiveStudiesGettinga“layoftheland”Surveys(NHIS,MCBS)“HowmanymenintheU.S.filledViagraprescriptionsin2004?”DescribinganovelphenomenaCasereportsorcaseseriesViagra-associatedserousmaculardetachment.Sildenafil-associatednonarteriticanteriorischemicopti

4、cneuropathy.8/2/20218DescriptiveStudiesCannotestablishcausalrelationshipsStillplayanimportantroleindescribingtrendsandgeneratinghypothesesaboutnovelassociationsThestartofHIV/AIDSresearchSquamouscellcarcinomainsexualpartnerofKaposisarcomapatient.Lancet.1982Jan30;1(82

5、66):286.Newoutbreakoforaltumors,malignanciesandinfectiousdiseasesstrikesyoungmalehomosexuals.CDAJ.1982Mar;10(3):39-42.AIDSinthe"gay"areasofSanFrancisco.Lancet.1983Apr23;1(8330):923-4.8/2/20219AnalyticStudiesAttempttoestablishacausallinkbetweenapredictor/riskfactoran

6、danoutcome.Youaredoingananalyticstudyifyouhaveanyofthefollowingwordsinyourresearchquestion:greaterthan,lessthan,causes,leadsto,comparedwith,morelikelythan,associatedwith,relatedto,similarto,correlatedwith8/2/202110HierarchyofStudyTypesDescriptiveCasereportCaseseries

7、SurveyAnalyticObservationalCrosssectionalCase-controlCohortstudiesExperimentalRandomizedcontrolledtrialsStrengthofevidenceforcausalitybetweenariskfactorandoutcome8/2/202111ResearchQuestionIstheregularconsumptionofRedBullassociatedwithimprovedacademicperformanceamong

8、U.S.medicalstudents?8/2/202112Rationale“functionaldrink”designedforperiodsofmentalandphysicalexertion.performance,concentration,memory,rea