有机合成化学-5复习过程.ppt

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1、有机合成化学-5Glaser(Hay)Coupling2ModernOrganicSynthesisSuzukiCoupling3ModernOrganicSynthesisSonogashiraReaction4ModernOrganicSynthesis5ModernOrganicSynthesisAminationReaction6ModernOrganicSynthesis7ModernOrganicSynthesisStillereaction8ModernOrganicSynthesis9ModernOrganicSynthesisTheKumadaCoup

2、lingwasthefirstPdorNi-catalyzedcrosscouplingreaction,developedin1972.Kumadareaction10ModernOrganicSynthesis11ModernOrganicSynthesisNegishireaction12ModernOrganicSynthesis13ModernOrganicSynthesis14ModernOrganicSynthesisFukuyamaCoupling15ModernOrganicSynthesis16ModernOrganicSynthesisHeckre

3、action17ModernOrganicSynthesis18ModernOrganicSynthesis过渡金属催化的烯烃、炔烃复分解反应Metathesis２００５年度诺贝尔化学奖"forthedevelopmentofthemetathesismethodinorganicsynthesis".19ModernOrganicSynthesisYvesChauvin，伊夫·肖万l'Institutfrançaisdupétrole,Rueil-Malmaison,France.RobertH.Grubbs,罗伯特·格拉布CaliforniaInstituteofT

4、echnologyRichardR.Schrock,理查德·施罗克MassachusettsInstituteofTechnology20ModernOrganicSynthesisMetathesis–achange-your-partnersdanceMetathesiscanbeviewedasadanceoftwomolecules,withacatalystpair(left)thatincludesametal(black)joining"hands"withanalkene(yellow/red)pair.Thepairthenjoininacircle(

5、center),andthengooffwithdifferentpartners(right).21ModernOrganicSynthesisThisyear'sNobelPrizeLaureatesinchemistryhavemademetathesisintooneoforganicchemistry'smostimpor-tantreactions.Fantasticopportunitieshavebeencreatedforproducingmanynewmolecules-pharmaceuticals,forexample.Imaginationwi

6、llsoonbetheonlylimittowhatmoleculescanbebuilt!22ModernOrganicSynthesis烯烃复分解反应23ModernOrganicSynthesis24ModernOrganicSynthesis25ModernOrganicSynthesis26ModernOrganicSynthesisGrubbs催化剂的制备27ModernOrganicSynthesis28ModernOrganicSynthesis29ModernOrganicSynthesis炔烃复分解反应30ModernOrganicSynthesis

7、31ModernOrganicSynthesis32ModernOrganicSynthesis33ModernOrganicSynthesis过渡金属催化的偶联反应反应最新研究进展GeneralIntroductionCross-CouplingReactionHeckCoupling:Heck,R.F.J.Am.Chem.Soc.1968,90,551834ModernOrganicSynthesisKumadaCoupling:Tamao,K.;Kiso,Y.;Sumitani,K.;Kumada,M.J.Am.Chem.Soc.1