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时间:2017-12-30
《多西紫杉醇联合顺铂与联合奈达铂化疗方案治疗晚期非小细胞肺癌的临床观察》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、万方数据新疆医科大学学报JOURNAI,oFXINJIANGMEDICAl。UNTVERSITY2009Jul.,32(7)901多西紫杉醇联合顺铂与联合奈达铂化疗方案治疗晚期非小细胞肺癌的临床观察王强‘,单利”(新疆医科大学附属肿瘤医院内一科.新疆乌鲁木齐830011)摘要:目的:观察多西紫杉醇联合顺铂化疗方案与多西紫杉醇联合奈达铂方案治疗中晚期(III。、Ⅳ期)非小细胞肺癌(nonsmallcelllungcancer。NSCLC)的疗效及不良反应。方法:62例中晚期非小细胞肺癌患者,其中多西紫杉醇联合顺铂化疗方案组(A组)32例,多西紫杉醇联合奈达铂方案组(B组
2、)30例。结果:A组有效率(37.5%)B组有效率(38.7%)无显著差异(P>O.05);A组胃肠道反应(77.4%)发生率明显高于B组(60%)(P3、码:A文章编号:1009—5551(2009)07—0901—04Clinicalobservationoftheregimenfordocetaxelcombinedwithcisplatinanddedaplainchemotherapyinthetreatmentofadvancednon’smallcelllungcancerWANGQiang,SHANLi(FirstDepartmentofMedicalOncology,AffiliatedTumorHospital,XinjiangMedicalUniversity,Urumqi830011,China)4、Abstract:Objective:TodetecttheefficacyandthesideeffectoftheregimenfordocetaxelcombinedwithcisplatinandNedaplatinchemotherapyinthetreatmentwithadvancednon—smallcelllungcancer.Meth—ods:AtotaIof62patientswithadvancednon-smallcelllungcancerweredividedintothedocetaxeIcorn—binedwithcisplating5、roup(groupA,n一32)andthedocetaxelcombinedwithNedaplatingroup(groupB72—30).Results:TheefficacyofgroupAwas37.5%andgroupBwas38.7%,therewasnosignificantdifferencebetweenthetwogroupsincurativeeffect(P>O.05).Ahigherresponserateofdigestivereac—tionandnephrotoxicity(77.4%)occurredingroupA,compar6、edtOthatoccurredingroupB(60%),withasignificantdifferencebetweenthetwogroups(P<0.01).TherewasnosignificantdifferencebetweentWOgroupsinthetoxicityofkidney.Therewasalowerincidenceofleucopeniaresponserate(50%)ingroupAthaningroupB(76.67%),withasignificantdifferencebetweenthegroups(P7、erewasalowerthrombocytopeniaresponserate(6.3%)ingroupAthaningroupB(26.67oA),withasignifi—cantdifferencebetweenthegroups(P
3、码:A文章编号:1009—5551(2009)07—0901—04Clinicalobservationoftheregimenfordocetaxelcombinedwithcisplatinanddedaplainchemotherapyinthetreatmentofadvancednon’smallcelllungcancerWANGQiang,SHANLi(FirstDepartmentofMedicalOncology,AffiliatedTumorHospital,XinjiangMedicalUniversity,Urumqi830011,China)
4、Abstract:Objective:TodetecttheefficacyandthesideeffectoftheregimenfordocetaxelcombinedwithcisplatinandNedaplatinchemotherapyinthetreatmentwithadvancednon—smallcelllungcancer.Meth—ods:AtotaIof62patientswithadvancednon-smallcelllungcancerweredividedintothedocetaxeIcorn—binedwithcisplating
5、roup(groupA,n一32)andthedocetaxelcombinedwithNedaplatingroup(groupB72—30).Results:TheefficacyofgroupAwas37.5%andgroupBwas38.7%,therewasnosignificantdifferencebetweenthetwogroupsincurativeeffect(P>O.05).Ahigherresponserateofdigestivereac—tionandnephrotoxicity(77.4%)occurredingroupA,compar
6、edtOthatoccurredingroupB(60%),withasignificantdifferencebetweenthetwogroups(P<0.01).TherewasnosignificantdifferencebetweentWOgroupsinthetoxicityofkidney.Therewasalowerincidenceofleucopeniaresponserate(50%)ingroupAthaningroupB(76.67%),withasignificantdifferencebetweenthegroups(P7、erewasalowerthrombocytopeniaresponserate(6.3%)ingroupAthaningroupB(26.67oA),withasignifi—cantdifferencebetweenthegroups(P
7、erewasalowerthrombocytopeniaresponserate(6.3%)ingroupAthaningroupB(26.67oA),withasignifi—cantdifferencebetweenthegroups(P
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