HPV (HPV及常用试剂盒)ppt课件.ppt

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1、HPVBurdenoftheworldVicky.hu20140905Contents1WhatisHPV2HPVtypesandlinkeddisease3HPVdetectionmethods4HPVdetectionproducts2Contents1WhatisHPV3WhatisHPVHPV(Humanpapillomavirus)Non-envelopeddouble-strandedDNAvirusMorethan100typesCauseswartsonacralpartsHPVinfectionisthem

2、ostcommonviralsexuallytransmitteddiseaseMostHPVinfectionsaresubclinicalandtransitory,themediandurationofinfectionbeingabout8months,withpersistenceratesof30%at1yearand9%at2years.4ClassificationofHPVsMainlybasedonthemosthighlyconservedORL(L1)56Contents2HPVtypesandlin

3、keddisease7HPVtypesMorethan100typesofHPVatleast13arecancer-causing(alsoknownashighrisktype).HPVinfectionsusuallyclearupwithoutanyinterventionwithinafewmonthsafteracquisition,andabout90%clearwithintwoyearsRegionaldistribution8NatureVolume:488,Pages:S2–S3Datepublishe

4、d:(30August2012)DOI:doi:10.1038/488S2a9HPVtypeslinkeddiseaseHumandiseasesassociatedwithHPVandthemostcommonHPVtypesassociatedwiththosediseasesHumanpapillomavirusesarecommonthroughouttheworldHPVinfectionsaretransmittedthroughsexualcontactMostinfectionswithHPVcausenos

5、ymptoms104typeswomenandgirlsshouldbemostconcernedaboutHPVTypes16and18causeabout70%ofcervicalcancercases.HPVTypes6and11causeabout90%ofgenitalwartsrespiratorypapillomatosis111213HPVandcervicalCancerCervicalcancerisbyfarthemostcommonHPV-relateddiseaseTwoHPVtypes(16and

6、18)cause70%ofcervicalcancersandprecancerouscervicallesionsHighrisk(FDA):HPV1618313335394551525658596668Lowrisk:HPV611424344NatureVolume:488,Pages:S2–S3Datepublished:(30August2012)DOI:doi:10.1038/488S2a14ThecarcinogenicmechanismofHPV15CancermodelinducedbyHPV16Conten

7、ts3HPVdetectionmethods17HPVdetectionmethodsCytologyConventionalPapsmearLiquid-basedcytologyPAPNET,AutoPapVisualinspectionVIA(visualinspectionwithaceticacid)3%-5%glacialaceticacidVILI(visualinspectionwithlugol’iodin)4%-5%Lugol’siodinColposcopyPathogendetectionImmuno

8、logyHPVDNAdetection182012screeningguidelinesAmericanCancerSociety,AmericanSocietyforColposcopyandCervicalPathology,andAmericanSocietyforClinicalP