前列腺癌组织EZH2基因表达及其意义.doc

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1、前列腺癌组织EZH2基因表达及其意义作者：宋力，崔小健，苏大军，谭国良【关键词】前列腺肿瘤；基因；EZH2ExpressionprofileandsignificanceofEZH2geneinprimaryprostatecance[Abstract]AIM：TodeterminetheexpressionofEZH2geneinprostatecancer(PCa)andtoinvestigatetherelationbetweenEZH2expressionandbiologicalcharactersofPCa.METHODS:

2、In40casesofPCa,20casesofbenignprostatehyperplasia(BPH),20casesofprostaticintraepithelialneoplasia(PIN),theexpressionofEZH2wasdetectedbysemiquantitativeRTPCRandtheamplifiedproductwassequenced.RESULTS：All40PCacaseswerepositiveinEZH2expression.TherewasnoexpressionofEZH2gene

3、inBPH.Onlyoneofthe20PINcaseswasseenEZH2expressedpositively.EZH2expressionwasincreasedintheadvancedcomparedwiththeprimaryPCa(P<0.05),inthelowdifferentiatedcomparedwiththehighlydifferentiatedPCa(P<0.05)andinthehormonedependentcomparedwiththehormoneindependentPCa前列腺癌组织EZH2基

4、因表达及其意义作者：宋力，崔小健，苏大军，谭国良【关键词】前列腺肿瘤；基因；EZH2ExpressionprofileandsignificanceofEZH2geneinprimaryprostatecance[Abstract]AIM：TodeterminetheexpressionofEZH2geneinprostatecancer(PCa)andtoinvestigatetherelationbetweenEZH2expressionandbiologicalcharactersofPCa.METHODS:In40casesof

5、PCa,20casesofbenignprostatehyperplasia(BPH),20casesofprostaticintraepithelialneoplasia(PIN),theexpressionofEZH2wasdetectedbysemiquantitativeRTPCRandtheamplifiedproductwassequenced.RESULTS：All40PCacaseswerepositiveinEZH2expression.TherewasnoexpressionofEZH2geneinBPH.Onlyo

6、neofthe20PINcaseswasseenEZH2expressedpositively.EZH2expressionwasincreasedintheadvancedcomparedwiththeprimaryPCa(P<0.05),inthelowdifferentiatedcomparedwiththehighlydifferentiatedPCa(P<0.05)andinthehormonedependentcomparedwiththehormoneindependentPCa(P<0.05).However,EZH2e

7、xpressiondidnothavealinearcorrelationwiththeserumtotalprostatespecificantigenlevel(P>0.05).CONCLUSION：EZH2geneplaysanimportantroleinthedevelopmentofprostaiccarcinoma.Therefore,theanalysisofEZH2expressionwillbenefitthediagnosisandtreatmentofprostaticcarcinoma.[Keywords]pr

8、ostaticcarcinoma；gene；EZH2【摘要】目的：探讨EZH2基因在列腺癌组织中的表达意义.方法：采用半定量RT-PCR检测前列腺癌、前列腺上皮内瘤(PIN),良性前列腺增生中EZH2表达状