轻型颅脑损伤患者血清UCH-L1变化的临床意义和患者预后关系-论文.pdf

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1、·论善·JMedRes，Jul2014，Vo1．43No．7轻型颅脑损伤患者血清UCH—L1变化的临床意义和患者预后关系葛岭薛龙黄晓伟陈洁波许静摘要目的探讨轻型颅脑损伤(mildtraumaticbraininjury，mTBI)后患者血清泛素c末端水解酶Ll(ubiquitinC—termi-nalhydrolase—L1，UCH—L1)含量的临床意义和患者预后关系。方法用ELISA法检测56例轻型颅脑损伤患者血清UCH—L1含量并与30例体检健康患者比较。对比27例头颅CT阴性和29例头颅cT阳性mTBI患者血清UCH—L1含量。评估

2、患者6个月后GOS—E评分和mTBI患者血清UCH—L1含量的关系。结果轻型颅脑损伤患者血清UCH—L1含量显著高于正常对照组(P<0．05)。mTBI后头颅cT阳性和阴性患者血清UCH—L1含量比较有统计学意义，血清UCH—L1含量在鉴别mTBI患者时有较高的敏感度(82．8％)和特异性(70．4％)。血清UCH—L1含量越高患者预后越差，但其不能单独作为头颅cT阴性患者预后判断指标。结论UCH—L1可作为轻型颅脑损伤诊断的生物标志物，并有较高的特异性和敏感度。血清UCH—L1含量越高患者预后越差，但UCH—L1不能单独判断头颅CT阴性

3、mTBI患者预后。关键词UCH—L1轻型颅脑损伤GOS—E[中图分类号]R74[文献标识码]ARelationshipbetweenthePrognosisafterMildTraumaticBrainInjury(mTBI)andSerumUbiquitinC—terminalHydrolase—L1(UCH—L1)Change．GeLing，XueLong，HuangXiaowei，eta1．DepartmentofNeurosurgery，YangpuHospital，Tong]iUniversitySchoolofMed—icin

4、e，Shanghai200090，ChinaAbstractObjectiveToexploretheclinicalsignificanceofserumubiquitinC—terminalhydrolase—L1(UCH—L1)changeinpa—tientsaftermildtraumaticbraininjury(mTBI)，andtherelationshipbetweenUCH—L1andprognosis．MethodsSerumUCH—L1con。tentwasdetectedbyELISAandComparative

5、Studyin56casesofmildheadinjurypatientsand30healthysubjectswasperpormed．TheserumconcentrationsofUCH—-L1wascomparedbetweenthe27casesofcranialCTnegativepatientsaftermTBIandthe29casesofcrani-alCTpositivepatientsaftermTBI．TherelationshipwasassessedbetweentheGOS—Escoreofpatient

6、after6monthsandUCH—L1．ResultsTheserumconcentrationsofUCH—L1betweenpatientsandthecontrolgroupwasstatisticallysignificant(P<0．05)．Theser-umUCH—-L1concentrationbetweenthepatientswithcranialCTpositiveandthosewithcranialCTnegativewasstatisticallysignificant．Ithadhighsensitivit

7、y(82．8％)andspecificity(70．4％)todiscriminatebetweenthepatientswithcranialCTpositiveandthosewithcranialCTnegativebytheserumUCH—L1concentration．ThehighertheconcentrationofserumUCH—L1，theworsetheprognosis，butitisnotaprognosticindicatorincranialCTnegativepatients．ConclusionSer

8、umconcentrationsofUCH—L1canbeusedasmTBIdiagnosticbi—omarkers，andhavehighspecificityandsensitivit