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时间:2020-05-02
《全麻复合硬膜外阻滞行腹腔镜胆囊切除术对老年患者应激反应的影响.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·l228·临嘛医学工程2013年10月第20卷第10期·论著·(临床研究)全麻复合硬膜外阻滞行腹腔镜胆囊切除术对老年患者应激反应的影响吴静波,蔡杰衡,吴志镇(广东药学院附属第一医院麻醉科,广东广州510080)【摘要】目的研究全麻复合硬膜外阻滞行腹腔镜胆囊切除术对老年患者应激的影响,为全麻复合硬膜外麻醉的临床应用提供理论依据。方法40例ASAI~Ⅱ级择期行腹腔镜胆囊切除手术病人(年龄>65岁),随机双盲分为全麻组(A组)和全麻复合硬膜外阻滞组(B组),每组20例。并于麻醉前(T1),气管插管后5min(T2),气腹后5min(T3),术毕前5min(
2、T4),拔管后5min(T4)抽静脉血,检测血浆标本中血糖浓度、皮质醇、血管紧张素1I、白介素一6(IL一6)。采用SPSS10.0及SigmaPlot统计绘图软件分析处理数据。结果A组血流动力学气管插管后较B组波动大(P<0.O5)。A组在T2、T3、T5时血糖浓度显著高于B组(P<0.O5)。两组血管紧张素II在麻醉后各时间段相比有显著性差异(P3、麻组【关键词】硬膜外阻滞;全身麻醉;皮质醇;血管紧张素11;白介素一6中图分类号:R614文献标识码:Adoi:10.3969~.issn.1674—4659.2013.10.1228EfectofGeneralAnesthesiaCombinedwithEpiduralBlockonStressResponsesinElderlyPatientsUndergoingLaparo-scopicCholecystectomy//f/n0,CAIJieheng,Zh~hen(DepartmentOfAnesthesiology,theFirstAfilia4、tedHospitdofGuangdongPharmaceuticalUniversity,Guangzhou510080,China)[Abstract】ObjectiveToevaluatetheeficacyofgeneralanesthesiacombinedwithepiduralblockonstressresponsesinelderlypatientsundergoinglaparoscopiccholecystectomy.MethodsFortypatients(>65yearsold,ASAI~1)withlaparoscopic5、cholecystectomywererandomlydividedintotwogroups:groupA(generalanesthesia,n=20)andgroupB(generalanesthesiacombinedwithepiduralanesthesia,n=20).TheplasmacontentsofBloodsugar(BS),cortisol,angiotensin1(Ag-I)Interleukin-6atthefollowingtimepointsofbeforeanesthesia(T1),after5minintubat6、ion(T2),5minaltertheartificialpneumoperitoneum(T3),beforetheoperationfinishedtime(T4)andafterextubation(T5)weremeasured.ResultsIngroupMAP,HRatthetimeofT2,T3andT4washi【gherthanthatingroupB<0.05).ThelevelofplasmaglucoseingroupBattimeofT4,T5washigherthanthelevelbeforeanesthesia(P<07、.05).ThelevelofplasmacortisolinthetwogroupsatvarioustimewassignificantlylowerthanthelevelsattimeofT2(P8、rthanlevelofplasmaInterleukin一6inthegroupA(尸<0.
3、麻组【关键词】硬膜外阻滞;全身麻醉;皮质醇;血管紧张素11;白介素一6中图分类号:R614文献标识码:Adoi:10.3969~.issn.1674—4659.2013.10.1228EfectofGeneralAnesthesiaCombinedwithEpiduralBlockonStressResponsesinElderlyPatientsUndergoingLaparo-scopicCholecystectomy//f/n0,CAIJieheng,Zh~hen(DepartmentOfAnesthesiology,theFirstAfilia
4、tedHospitdofGuangdongPharmaceuticalUniversity,Guangzhou510080,China)[Abstract】ObjectiveToevaluatetheeficacyofgeneralanesthesiacombinedwithepiduralblockonstressresponsesinelderlypatientsundergoinglaparoscopiccholecystectomy.MethodsFortypatients(>65yearsold,ASAI~1)withlaparoscopic
5、cholecystectomywererandomlydividedintotwogroups:groupA(generalanesthesia,n=20)andgroupB(generalanesthesiacombinedwithepiduralanesthesia,n=20).TheplasmacontentsofBloodsugar(BS),cortisol,angiotensin1(Ag-I)Interleukin-6atthefollowingtimepointsofbeforeanesthesia(T1),after5minintubat
6、ion(T2),5minaltertheartificialpneumoperitoneum(T3),beforetheoperationfinishedtime(T4)andafterextubation(T5)weremeasured.ResultsIngroupMAP,HRatthetimeofT2,T3andT4washi【gherthanthatingroupB<0.05).ThelevelofplasmaglucoseingroupBattimeofT4,T5washigherthanthelevelbeforeanesthesia(P<0
7、.05).ThelevelofplasmacortisolinthetwogroupsatvarioustimewassignificantlylowerthanthelevelsattimeofT2(P8、rthanlevelofplasmaInterleukin一6inthegroupA(尸<0.
8、rthanlevelofplasmaInterleukin一6inthegroupA(尸<0.
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